Table 3. GMDR analysis on the best gene- gene and gene–smoking interaction models.

Locus no	Best combination	Cross-validation consistency	Testing accuracy	p-values
Gene- gene interactions*
2	rs2228529 rs2228527	8/10	0.5399	0.0547
3	rs2228529 rs2228527 rs1799793	7/10	0.5399	0.1719
4	rs2228529 rs2228527 rs1799793 rs4134822	5/10	0.4958	0.3770
Gene- smoking interactions*
2	rs2228529 current smoking	9/10	0.6072	0.0010
3	rs2228529 rs2228527 current smoking	7/10	0.4958	0.3770
4	rs2228529 rs2228527 rs1799793 current smoking	6/10	0.4958	0.4258
5	rs2228529 rs2228527 rs1799793 rs4134822 current smoking	5/10	0.5399	0.6230

*Adjusted for gender, age, BMI, smoking and alcohol drinking.

**Adjusted for gender, age, BMI and alcohol drinking.