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. 2017 Sep 15;8(46):81001–81013. doi: 10.18632/oncotarget.20944

Figure 4. PLGA NPs reduced Aβ40 and Aβ42 levels in AD mouse brains.

Figure 4

The levels of soluble Aβ40 (A) and Aβ42 (B), insoluble Aβ40 (C) and Aβ42 (D) in the brain lysates of AD mice treated with NP control, NP-S1, NP-Cur, NP-S1+Cur and CRT-NP-S1+Cur were detected by Aβ40 and Aβ42 sandwich ELISA kits, respectively. The senile plaques in the brains of AD transgenic mice treated with NP control, NP-S1, NP-Cur, NP-S1+Cur and CRT-NP-S1+Cur were detected by immunohistochemistry (E) and quantitatively analyzed by Image-Pro Plus software (F) (*, P < 0.05, **, P < 0.01, compared with NP control-treated AD mice).