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. 2017 Sep 15;8(46):81001–81013. doi: 10.18632/oncotarget.20944

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Copyright: © 2017 Huang et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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(A) Microgliosis and astrogliosis in the brains of AD mice treated with NP control, NP-S1, NP-Cur, NP-S1+Cur and CRT-NP-S1+Cur were detected by IBA-1 and GFAP immunostaining, and qualified by Image-Pro Plus software (B), respectively. The protein levels of GFAP and Iba-1 in the brain lysates of AD transgenic mice were detected by western blot (C) and quantitatively analyzed by ImageQuant software (D). GAPDH was used as a loading control (*, P < 0.05, **, P < 0.01, ***, P < 0.001, compared with AD control mice).