Table 3. Summary of hazard ratios of miRNA expression in osteosarcoma.

MiRNA	No. of studies	No. of patients	Survival outcome	Effects model	HR (95% CI)	P value	Heterogeneity	Reference
MiR-21	4	218	OS	Random	2.60 (1.39–4.89)	0.003*	I2 = 65.0%; P = 0.036	[5, 53, 54, 61]
MiR-214	3	166	OS	Fixed	3.81 (2.13–6.83)	< 0.001*	I2 = 42.8%; P = 0.174	[43–45]
MiR-382	2	171	OS	Fixed	0.51 (0.29–0.87)	0.013*	I2 = 16.6%; P = 0.274	[55, 57]
MiR-382	2	184	MFS	Fixed	0.45 (0.30–0.67)	< 0.001*	I2 = 21.0%; P = 0.261	[56, 57]
MiR-26a	2	236	OS	Fixed	0.43 (0.29–0.62)	< 0.001*	I2 = 0.0%; P = 0.876	[3, 4]
MiR-29a	2	127	OS	Fixed	2.66 (1.53–4.63)	0.001*	I2 = 46.0%; P = 0.174	[5, 41]
MiR-221	2	135	OS	Random	3.28 (0.76–14.28)	0.113	I2 = 85.5%; P = 0.009	[5, 42]
MiR-221	2	135	RFS	Random	2.92 (0.69–12.28)	0.144	I2 = 82.3%; P = 0.017	[5, 42]
MiR-126	2	149	OS	Random	0.56 (0.34–0.94)	0.029*	I2 = 67.0%; P = 0.082	[5, 46]
MiR-195	3	372	OS	Fixed	0.38 (0.27–0.54)	< 0.001*	I2 = 0.0%; P = 0.745	[47, 48]
MiR-124	2	174	OS	Fixed	0.34 (0.21–0.57)	< 0.001*	I2 = 0.0%; P = 0.810	[49, 50]
MiR-9	2	197	OS	Fixed	4.25 (3.10–5.84)	< 0.001*	I2 = 38.6%; P = 0.202	[51, 52]
MiR-148a	2	181	OS	Random	2.29 (1.26–4.16)	0.006*	I2 = 53.3%; P = 0.143	[58, 59]
MiR-92a	2	72	OS	Random	1.84 (0.81–4.17)	0.143	I2 = 84.3%; P = 0.012	[5, 60]

OS: overall survival; RFS: recurrence-free survival; MFS: metastasis-free survival.