Table 2. The pooled data on overall survival of meta-analysis.
| Subgroup analysis | Pooled HR (95% CI) | Meta-regression (p value) | Heterogeneity | ||
|---|---|---|---|---|---|
| Random-effect model | Fixed-effect model | I2 value (%) | p value | ||
| Year | 0.114 | ||||
| ≤ 2010 | 1.69 (1.30–2.20) | 1.37 (1.21–1.55) | 59.40 | 0.016 | |
| > 2010 | 1.77 (1.25–2.51) | 1.74 (1.38–2.19) | 52.50 | 0.032 | |
| Country | 0.094 | ||||
| Asia | 1.55 (1.24–1.94) | 1.46 (1.25–1.71) | 33.80 | 0.15 | |
| Non–Asia | 2.26 (1.42–3.61) | 1.43 (1.23–1.66) | 72.0 | 0.001 | |
| HR estimation | 0.036 | ||||
| From curves | 1.37 (1.16–1.63) | 1.33 (1.17, 1.50) | 52.0 | 0.02 | |
| Directly obtained | 2.08 (1.47–2.95) | 1.92 (1.53–2.40) | 21.10 | 0.28 | |
| Scoring criteria | 0.364 | ||||
| Percentage | 1.72 (1.32–2.24) | 1.69 (1.37–2.09) | 29.9 | 0.179 | |
| Semiquantitative | 2.50 (1.39–4.51) | 2.46 (1.70–3.55) | 56.2 | 0.077 | |
| Combined | 1.25 (1.08–1.43) | 1.25 (1.08–1.43) | 0.2 | 0.367 | |
| NOS | 0.819 | ||||
| 6 | 2.33 (0.95–5.73) | 1.54 (1.11–2.14) | 75.3 | 0.017 | |
| 7 | 1.62 (1.23–2.12) | 1.37 (1.21–1.55) | 58.3 | 0.014 | |
| 8 | 2.01 (1.31–3.09) | 1.93 (1.37–2.72) | 24.9 | 0.26 | |
| Histological type | 0.425 | ||||
| Serious | 1.84 (1.33–2.53) | 1.81(1.37–2.40) | 18.4 | 0.29 | |