Table 4. Comparison of ROC curves for serum miR-4651 and AFP.
| AUC (95% CI) | Sensitivity (%) | Specificity (%) | p-value* | |
|---|---|---|---|---|
| Group 4 vs Group 1 | ||||
| miR-4651 | 0.89 (0.86-0.92) | 78.1 | 99.1 | - |
| AFP20 | 0.81 (0.77-0.84) | 61.3 | 100.0 | <0.001/<0.001/0.25 |
| AFP400 | 0.72 (0.67-0.76) | 43.0 | 100.0 | <0.001/<0.001/0.25 |
| miR-4651 +AFP20 | 0.91 (0.88-0.93) | 81.0 | 100.0 | 0.35/0.40/0.25 |
| miR-4651 +AFP400 | 0.92 (0.89-0.94) | 83.2 | 100.0 | 0.14/0.13/0.25 |
| Group 4 vs Group 2 | ||||
| miR-4651 | 0.82 (0.78-0.85) | 78.1 | 85.3 | - |
| AFP20 | 0.81 (0.77-0.84) | 61.3 | 100.0 | 0.68/<0.001/<0.001 |
| AFP400 | 0.72 (0.67-0.76) | 43.0 | 100.0 | <0.001/<0.001/<0.001 |
| miR-4651 +AFP20 | 0.85 (0.81-0.88) | 81.0 | 88.4 | 0.24/0.40/0.27 |
| miR-4651 +AFP400 | 0.89 (0.86-0.92) | 83.2 | 94.5 | 0.003/0.13/<0.001 |
| Group 4 vs Group 3 | ||||
| miR-4651 | 0.80 (0.71-0.88) | 781. | 81.2 | - |
| AFP20 | 0.68 (0.59-0.78) | 61.3 | 75.0 | 0.07/<0.001/0.55 |
| AFP400 | 0.72 (0.65-0.90) | 43.0 | 100.0 | 0.13/2.08×10−17/0.02 |
| miR-4651 +AFP20 | 0.83 (0.75-0.90) | 81.0 | 84.4 | 0.60/0.40/0.74 |
| miR-4651 +AFP400 | 0.87 (0.81-0.93) | 83.2 | 90.6 | 0.18/0.13/0.47 |
| Group 4 vs Group 1+2+3 | ||||
| miR-4651 | 0.85 (0.82-0.88) | 78.1 | 92.1 | - |
| AFP20 | 0.80 (0.76-0.84) | 61.3 | 98.8 | 0.06/<0.001/<0.001 |
| AFP400 | 0.72 (0.67-0.77) | 43.0 | 100.0 | <0.001/<0.001/<0.001 |
| miR-4651 +AFP20 | 0.88 (0.85-0.91) | 81.0 | 94.1 | 0.25/0.40/0.16 |
| miR-4651 +AFP400 | 0.90 (0.87-0.93) | 83.2 | 97.1 | 0.02/0.13/<0.001 |
*The p value indicates the statistical significance for the differences of AUC/sensitivity/specificity as compared with miR-4651. Abbreviations: ROC, the receiver-operating characteristic; AFP, α-fetoprotein; AUC, the area under the ROC curve; AFP20, the cutoff of 20 ng/mL AFP; AFP400, the cutoff of 400 ng/mL AFP; CmiR+AFP20, the combination of miR-4651 and AFP20; CmiR+AFP400, the combination of miR-4651 and AFP400.