Table 6. Comparison of ROC curves for serum miR-4651 and AFP based on the early HCC with positive AFB1.
| Variable | AUC (95% CI) | Sensitivity (%) | Specificity (%) | p-value* |
|---|---|---|---|---|
| miR-4651 | 0.84 (0.79-0.89) | 75.7 | 92.1 | - |
| AFP20 | 0.69 (0.63-0.75) | 38.7 | 98.8 | <0.001/<0.001/<0.001 |
| AFP400 | 0.63 (0.56-0.69) | 25.2 | 100.0 | <0.001/<0.001/<0.00110−13 |
| miR-4651 +AFP20 | 0.80 (0.75-0.89) | 65.8 | 94.1 | 0.29/0.11/0.16 |
| miR-4651 +AFP400 | 0.84 (0.79-0.89) | 71.2 | 97.1 | 0.93/0.45/<0.001 |
*The p value indicates the statistical significance for the differences of AUC/sensitivity/specificity as compared with miR-4651. Abbreviations: ROC, the receiver operating characteristic curve; AFP, α-fetoprotein; AUC, the area under the ROC curve; AFP20, the cutoff of 20 ng/mL AFP; AFP400, the cutoff of 400 ng/mL AFP.