Table 2. Unadjusted and adjusted effects of liver morphological and functional parameters on all cause mortality in treatment-naïve cancer patients at the time of first diagnosis (n = 555).
| Variables | IQR | Crude HR (95%CI) | P-value | Adj. HR1 (95%CI) | P-value |
|---|---|---|---|---|---|
| BChE, kU/l (IQR) | 2.30 | 0.51 (0.42-0.62) | <0.001 | 0.55 (0.44-0.69) | <0.001 |
| Albumin, g/l (IQR) | 5.4 | 0.55 (0.47-0.64) | <0.001 | 0.64 (0.53-0.76) | <0.001 |
| AST, U/l (IQR) | 12 | 1.11 (1.07-1.15) | <0.001 | 1.12 (1.08-1.17) | <0.001 |
| ALT, U/l (IQR) | 16 | 1.15 (1.08-1.22) | <0.001 | 1.17 (1.10-1.24) | <0.001 |
| GGT, U/l (IQR) | 42 | 1.04 (1.02-1.06) | <0.001 | 1.03 (1.01-1.05) | 0.003 |
| Bilirubin, mg/dl (IQR) | 0.35 | 1.08 (1.05-1.11) | <0.001 | 1.09 (1.04-1.13) | <0.001 |
BChE – butyryl-cholinesterase, AST – aspartate transaminase, ALT – alanine transaminase, GGT – gamma glutamyltransferase, IQR – inter quartile range; fonts in bold indicate statistical significance (p < 0.05).
Cox proportional hazard models for all liver parameters are shown. Hazard ratios (HR) refer to an increase of one IQR in continuous variables. HRs are adjusted (adj.) for influencing variables, i.e. age, gender, kidney function, tumor entity and tumor stage, respectively.
1 HR adjusted to age, gender, kidney function (GFR), tumor stage and tumor entity.