Table 4. Comparison of genotype distribution frequencies of the allele and genotypes of polymorphic loci in the IS and control groups.

SNPs	Stroke (298 cases)	Control (303 cases)	AOR (95% CI)	P value
miR-149T>C
TT	131 (44.0)	121 (39.9)	1.000 (reference)
CT	127 (42.6)	136 (44.9)	1.108 (0.879–1.647)	0.756
CC	40 (13.4)	46 (15.2)	1.226(0.963–1.726)	0.301
Dominant model (TT vs CT + CC)			0.958(0.713–1.295)	0.363
Recessive model(TT + CT vs CC)			0.776(0.659–1.375)	0.575
T	389 (65.3)	378 (62.4)	1.000 (reference)
C	207 (34.7)	228 (37.6)	1.156 (0.916–1.597)	0.325
HWE P	0.300	0.447
miR-499A>G
AA	215 (72.1)	244 (80.5)	1.000 (reference)
AG	78 (26.2)	53 (17.5)	1.339 (1.126–1.967)	0.037
GG	5 (1.7)	6 (2.0)	1.077 (0.361–2.024)	0.669
Dominant model (AAvs AG + GG)			1.621 (1.079–2.516)	0.027
Recessive model (AA+ AG vs GG)			0.879 (0.531–2.557)	0.665
A	508 (85.2)	541 (89.3)	1.000 (reference)
G	88 (14.8)	65 (10.7)	1.455 (1.019–2.381)	0.039
HWE P	0.491	0.131
miR-146aC>G
CC	129 (43.3)	119 (39.3)	1.000 (reference)
CG	130 (43.6)	139 (45.9)	1.163(0.939–1.681)	0.596
GG	39 (13.1)	45 (14.9)	0.991(0.533–1.475)	0.557
Dominant model (CC vs CG + GG)			1.015 (0.623–1.273)	0.329
Recessive model (CC + CG vs GG)			1.006(0.543–1.319)	0.317
C	388 (65.1)	377 (62.2)	1.000(reference)
G	208 (34.9)	229 (37.8)	1.091 (0.075–1.451)	0.776
HWE P	0.490	0.672
miR-196a2T>C
TT	73 (24.5)	75 (24.8)	1.000 (reference)
CT	138 (46.3)	159 (52.5)	1.257 (0.976–2.058)	0.190
CC	87 (29.2)	69 (22.8)	1.339 (0.894–1.996)	0.216
Dominant model (TTvsCT + CC)			0.803 (0.576–1.127)	0.249
Recessive model (CCvsCT +TT)			1.376 (0.759–1.963)	0.173
T	284 (47.7)	309 (51.0)	1.000 (reference)
C	312 (52.3)	297 (49.0)	1.035 (0.799–1.541)	0.559
HWE P	0.215	0.385

Note: HWE P: Wendy–Harberger's law; miRNA: microRNA; 95% CI: 95% confidence interval; AOR: adjusted OR value.

Corrected factors of the AOR include gender, age, smoking, hypertension, diabetes, high Hcy, and high Lp(a).