Table 3. Time per preparation and administration of trastuzumab in the three scenarios.
| Scenario 1 | Scenario 2 | Δ (%) | Scenario 3 | Δ (%) | |
|---|---|---|---|---|---|
| Unit preparation time (sec) | 844 | 641 | –203 (24.1) | - | - |
| Overall preparation time (h) | 120 | 34 | –86 (71.7) | 78 | –42 (35) |
| Mean preparation time per patient (h) | 10.5 ± 6.3 | 3.0 ± 1.7 | –7.2 (71.7) | 6.8 ± 5.2 | –3.7 (35) |
| Unit administration time (min) | |||||
| Loading dose [No. of cycles] | 90 [85] | 5 [85] | –85 (94.4) | 90 [53]*; 5 [32] | 0 |
| Maintenance dose [No. of cycles] | 30 [1, 207] | 5 [1, 212] | –25 (83.3) | 30 [490]; 5 [717] | |
| Overall administration time (h) | 731 | 78 | –653 (89.3) | -387 | –344 (47) |
| Mean administration time per patient (h) | 6.4 ± 3.7 | 0.7 ± 0.4 | –5.7 (89.3) | 3.4 ± 3.2 | –3.0 (47) |
sec, seconds; h, hours; min, minutes
*The number of loading doses is lower than in scenario 1 because 32 patients received trastuzumab for the first time after chemotherapy and were thus directly “transferred” to subcutaneous trastuzumab.