Table 2. Pair-wise differences in the putamen FC.
| Brain regions | Side | Cluster size (mm3) | Coordinates MINI | Z value | ||
|---|---|---|---|---|---|---|
| X | Y | Z | ||||
| PD-A > PD-NA | ||||||
| Right putamen FC | ||||||
| Insula | R | 254 | 39 | -9 | -6 | 4.713 |
| Temporal pole | L | 167 | -39 | -3 | -15 | 4.343 |
| Middle occipital gyrus | L | 25 | -42 | -87 | -3 | 3.162 |
| Caudate | L | 33 | -15 | 15 | 18 | 3.976 |
| Middle cingulate gyrus | R | 36 | 12 | -6 | 33 | 3.208 |
| PD-A < PD-NA | ||||||
| Left putamen FC | ||||||
| Orbitofrontal gyrus | R | 13 | 18 | 60 | 3 | -3.130 |
| Right putamen FC | ||||||
| Cerebellum | R | 744 | 51 | -63 | -48 | -5.199 |
| Orbitofrontal gyrus | L | 143 | -6 | 63 | -3 | -3.744 |
| Precuneus | R | 26 | 0 | -45 | 72 | -3.981 |
| PD-A > HC | ||||||
| Right putamen FC | ||||||
| Paracentral lobule | L | 20 | 0 | -30 | 63 | 3.755 |
| Paracentral lobule | R | 21 | 6 | -24 | 75 | 3.590 |
| PD-A < HC | ||||||
| Left putamen FC | ||||||
| Anterior cingulate gyrus | L | 35 | -12 | 36 | 3 | -4.136 |
| Right putamen FC | ||||||
| Orbitofrontal gyrus | L | 24 | -6 | 39 | -9 | -3.490 |
| PD-NA > HC | ||||||
| Left putamen FC | ||||||
| Orbitofrontal gyrus | R | 107 | 6 | 63 | -21 | 4.773 |
| Right putamen FC | ||||||
| Orbitofrontal gyrus | L | 16 | -18 | 60 | -18 | 3.954 |
| Middle occipital gyrus | L | 139 | -27 | -102 | -9 | 4.113 |
| Paracentral lobule | R | 94 | 6 | -27 | 75 | 3.922 |
| PD-NA < HC | ||||||
| Left putamen FC | ||||||
| Anterior cingulate gyrus | L | 185 | -9 | 36 | 3 | -3.962 |
| Middle frontal gyrus | L | 136 | -33 | 42 | 15 | -3.903 |
| Postcentral gyrus | R | 117 | 27 | -39 | 48 | -4.222 |
| Right putamen FC | ||||||
| Cerebellum | R | 23 | 12 | -69 | -36 | -3.271 |
| Middle frontal gyrus | L | 18 | -15 | 54 | 3 | -3.012 |
| Middle cingulate gyrus | L | 18 | -3 | 0 | 33 | -3.501 |
Post hoc two sample t-tests with age, gender, education, HAMD scores and grey matter volume as covariates were performed to test differences between groups on the putamen FC. Note: FC, functional connectivity; MNI, Montreal Neurological Institute; HC, healthy controls; PD-A, Parkinson's disease patients with anxiety; PD-NA, Parkinson's disease patients without anxiety; Results are displayed at p < 0.05 corrected by AlphaSim.