Table 3. Adjusted hazard ratio (95% confidence interval) and p-value of hENT1, dCK, CDA and RRM1 on recurrence-free survival (RFS).
| RFS | ||||||||
|---|---|---|---|---|---|---|---|---|
| Variables | hENT1 | dCK | CDA | RRM1 | ||||
| HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |
| Biomarker | ||||||||
| Negative | 1 | 1 | 1 | 1 | ||||
| Positive | 0.62 (0.33–1.16) | 0.131 | 0.49 (0.24–0.98) | 0.043 | 1.09 (0.57–2.06) | 0.795 | 0.96 (0.50–1.83) | 0.895 |
| Vascular Invasion | ||||||||
| Absent | 1 | 1 | 1 | 1 | ||||
| Present | 2.29 (1.2–4.34) | 0.012 | 2.39 (1.25–4.58) | 0.009 | 2.19 (1.13–4.24) | 0.020 | 2.24 (1.17–4.28) | 0.015 |
| N stage | ||||||||
| N0 | 1 | 1 | 1 | 1 | ||||
| N1 | 2.92 (1.52–5.64) | 0.001 | 2.96 (1.52–5.78) | 0.001 | 2.68 (1.38–5.20) | 0.004 | 2.74 (1.41–5.32) | 0.003 |
* Variables to adjust were selected based on the univariable p-value < 0.2. Then these variables were included in the multivariable model together with each biomarker, and backward variable selection with an elimination criterion of p-value > 0.05 was applied. As a result, vascular invasion and N stage were adjusted for the evaluation of the adjusted hazard ratio of all four markers.