Table 3. Multivariate Cox proportional hazards models for RFS, TTR and OS.
| Full Model | Reduced Model | ||||||
|---|---|---|---|---|---|---|---|
| Characteristic | HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Recurrence-Free Survival (RFS) | (E/N = 103 /235) | (E/N = 108 /242) | |||||
| Age at Dx | 0.99 | (0.97, 1.01) | 0.25 | ||||
| Location of Tumor | Gastric vs. AEG 2/3 | 0.78 | (0.47, 1.30) | 0.34 | |||
| Baseline Stage | II vs. I | 1.21 | (0.64, 2.26) | 0.83 | |||
| III/IV vs. I | 1.10 | (0.59, 2.02) | |||||
| Tumor Grade | G3 Poorly Differentiated vs. G1/G2 Well/Moderately Differentiated | 1.74 | (0.93, 3.26) | 0.08 | |||
| p/yp Stage | I vs. 0 | 0.93 | (0.34, 2.55) | < 0.001 | 0.79 | (0.32, 1.94) | < 0.001 |
| II vs. 0 | 3.06 | (1.27, 7.41) | 3.02 | (1.41, 6.48) | |||
| III vs. 0 | 5.04 | (2.01, 12.66) | 4.82 | (2.24, 10.37) | |||
| IV vs. 0 | 31.79 | (9.25, 109.27) | 34.66 | (11.93, 100.72) | |||
| R Margin | R1 Resection vs. R0 Resection | 1.29 | (0.76, 2.18) | 0.34 | |||
| Total Gastrectomy | Yes vs. No | 1.24 | (0.81, 1.89) | 0.32 | |||
| Time to Recurrence | (E/N=74 /235) | (E/N=77 /242) | |||||
| Age at Dx | 0.98 | (0.96, 1.00) | 0.02 | 0.98 | (0.96, 0.99) | 0.01 | |
| Location of Tumor | Gastric vs. AEG 2/3 | 0.87 | (0.48, 1.59) | 0.65 | |||
| Baseline Stage | II vs. I | 1.43 | (0.64, 3.23) | 0.60 | |||
| III/IV vs. I | 1.48 | (0.69, 3.17) | |||||
| Tumor Grade | G3 Poorly Differentiated vs. G1/G2 Well/Moderately Differentiated | 2.26 | (0.95, 5.41) | 0.07 | |||
| p/yp Stage | I vs. 0 | 0.66 | (0.11, 4.04) | <0.001 | 0.75 | (0.13, 4.50) | < 0.001 |
| II vs. 0 | 6.00 | (1.41, 25.53) | 8.44 | (2.02, 35.18) | |||
| III vs. 0 | 10.43 | (2.39, 45.54) | 14.47 | (3.46, 60.55) | |||
| IV vs. 0 | 46.14 | (8.30, 256.67) | 81.31 | (16.00, 413.27) | |||
| R Margin | R1 Resection vs. R0 Resection | 1.17 | (0.64, 2.13) | 0.60 | |||
| Total Gastrectomy | Yes vs. No | 1.02 | (0.62, 1.67) | 0.95 | |||
| Overall Survival | (E/N=84 /235) | (E/N = 86 /241) | |||||
| Age at Dx | 1.01 | (0.99, 1.03) | 0.50 | ||||
| Location of Tumor | Gastric vs. AEG 2/3 | 0.84 | (0.47, 1.48) | 0.54 | |||
| Baseline Stage | II vs. I | 1.01 | (0.51, 1.98) | 0.89 | |||
| III/IV vs. I | 0.89 | (0.46, 1.74) | |||||
| Tumor Grade | G3 Poorly Differentiated vs. G1/G2 Well/Moderately Differentiated | 1.81 | (0.91, 3.61) | 0.09 | |||
| p/yp Stage | I vs. 0 | 0.84 | (0.30, 2.34) | < 0.001 | 0.78 | (0.31, 1.94) | < 0.001 |
| II vs. 0 | 1.95 | (0.79, 4.84) | 1.84 | (0.84, 4.06) | |||
| III vs. 0 | 3.63 | (1.40, 9.40) | 3.61 | (1.65, 7.91) | |||
| IV vs. 0 | 22.91 | (6.32, 83.04) | 21.50 | (6.74, 68.57) | |||
| R Margin | R1 Resection vs. R0 Resection | 1.29 | (0.71, 2.34) | 0.40 | |||
| Total Gastrectomy | Yes vs. No | 1.66 | (1.03, 2.67) | 0.04 | 1.73 | (1.11, 2.67) | 0.01 |
E = Events; N = Total; HR = Hazard Ratio; CI = Confidence Interval.