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(A) HOXA11-AS binds to several RNA binding proteins (PRC2, LSD1 and DNMT1) and function as a scaffold to inhibit PRSS8 and KLF2 at the transcriptional level to promote gastric cancer proliferation and invasion. (B) HOTAIR binding to PRC2 significantly inhibited miR-34a expression at the transcript level ultimately activating HGF/c-met signaling to promote EMT.
