Table 2. The ectopic expression of lncRNA in gastric cancer.

lncRNA	Relative Expression	Molecular Mechanism	Cell biology	Clinicopathologic feature	Reference
LINC00673	up	functioning as a scaffold for LSD1 and EZH2 and repressing KLF2 and LATS2 expression	Proliferation, tumor growth, invasion, metastasis and apoptosis	Tumor size, TNM Stage, lymphatic metastasis and poor prognosis	Huang et al. [86]
SNHG5	down	Sponge with miR-32 to regulate KLF4 expression	Proliferation and migration	negatively associated with miR-32	Zhao et al. [87]
LincRNAFEZF1-AS1	up	functioning as a scaffold for LSD1 and repressing p21 by inducing H3K4me2 demethylation	Proliferation, tumor growth and apoptosis	Tumor size, TNM Stage and poor prognosis	Liu et al. [88]
PVT1	up	PVT1 directly bound with FOXM1 protein to increase its stability, FOXM1 reversely bound to PVT1 promoter to promote its expression	Proliferation and metastasis	Tumor size, distant metastasis and poor prognosis	Xu et al. [89]
lncRNA-GHET1	up	GHET1 combined with IGF2BP1 protien up-regulates c-Myc by increasing c-Myc mRNA stability	proliferation	Tumor size, invasion and poor prognosis	Yang et al. [72]
TINCR	up	TINCR binds to STAU1 down-regulate KLF2 expression by influence its mRNA stability	Proliferation and apoptosis	TNM stage and lymphatic metastasis	Xu et al. [82]
ANRIL	up	ANRIL binds with PRC2 decreased miR-99a/miR-449a expression by interact with its promoter	proliferation	Tumor size, TNM stage and poor prognosis	Zhang et al. [81]
LincHOTAIR	up	HOTAIR silenced miR34a expression by recruiting PRC2 and finally activated HGF/c-Met /Snail pathway to promote gastric cancer EMT	Invasion and metastasis	Invasion depth, lymphatic metastasis and poor prognosis	Liu et al. [80]
GAPLINC	up	GAPLINC sponge with miR211-3p to regulate CD44 associated downstream signal	Proliferation and Invasion	Tumor size, lymphatic metastasis, TNM stage and poor prognosis	Hu et al. [90]
FENDRR	down	decreased FENDRR expression induces FN1 expression and activates MMPs family	Migration and Invasion	Invasion depth, TNM Stage, lymphatic metastasis and poor prognosis	Xu et al. [78]
H19	up	H19 directly binds with ISM1 to regulate its expression	proliferation, migration, invasion and metastasis	TNM Stage, lymphatic metastasis and poor prognosis	Li et al. [91]
FER1L4	down	FER1L4 liberated miR-106a-5p, downregulated PTEN expression	Proliferation and cell cycle	Tumor size, lymphatic metastasis, TNM stage and invasion depth	Xia et al. [92] Liu et al. [93]
GAS5	down	lncRNA GAS5 reduces the YBX1 protein and subsequently decreases YBX1-transactivated p21 expression	Cell cycle	-	Liu et al. [94]
nc886	down	nc886 knockdown activation of oncogenic FOS, NF-κB, and MYC as well as other pathways	proliferation	Poor prognosis	Lee et al. [95]
HOXA11-AS	up	HOXA11-AS functions as a scaffold for EZH2 and LSD1, HOXA11-AS acts as a ceRNA for miR-1297	Proliferation, cell growth, migration, invasion, and apoptosis	Tumor size, lymphatic metastasis, TNM stage and poor prognosis	Sun et al. [77]
GClnc1	up	GClnc1 bound WDR5 and KAT2A histone acetyltransferase, acted as a modular scaffold of WDR5 and KAT2A complexes, specified the histone modification pattern	proliferation, migration and invasion	Tumor size, Vascular metastasis, TNM stage and poor prognosis	Sun et al. [79]
BC032469	up	BC032469 bind to miR-1207-5p and effectively functioned as a sponge to modulate the derepression of hTERT	proliferation	Tumor size, poor proliferation and poor prognosis	Lu et al. [83]