| 1841 |
Scherer |
Discovery of hematoporphyrin by removing iron from dried blood |
| 1861–1871 |
L. Pasteur and P. Bert |
Discovery of phototoxicity |
| 1867 |
J.L.W. Thudichum |
Fluorescence spectrum of this red substance (hematoporphyrin) as well as fluorescence. |
| 1871 |
F.Hoppe-Seyler |
Naming of red substance (hematoporphyrin). |
| 1874 |
Schultz |
Description of a porphyria patient (errors in heme biosynthesis). |
| 1895–1903 |
N.R.Finsen |
Phototherapy (Nobel prize in 1903) |
| 1897–1904 |
O.Raaband H. von Tappeiner |
First reports on phototherapy |
| 1904 |
H. von Tappeiner |
Introduction of the term “photodynamic action” |
| 1903–1905 |
— |
First “before-and-after” photographs of patients (eosin+light) |
| 1908–1913 |
W.Hausmann, F.Meyer-Betz |
Many PDT experiments with hematoporphyrin on paramecia, erythrocytes, mice, guinea pigs, and humans. |
| 1924 |
— |
A.Policard saw red porphyrin fluorescence in tumors and first observation from tumors |
| 1925 |
H.Fischer |
Examination of porphyrins (Nobel prize in 1929). |
| 1945 |
S.Scwarz |
Radiosensitization with porphyrins. |
| 1959 |
D.Harman |
Proposed the free radical theory of ageing and disease. |
| 1960–1967 |
R.Lipson E.Baldes |
Synthesis of HpD. |
| 1970 |
H.Kautsky G.Herzberg |
Active oxygen. |
| 1975 |
Z.Malik M.Djaldetti |
ALA for PpIX induction. |
| 1983–1993 |
T.J.Dougherty, et al.
|
Photofrin®. |
| 1990 |
J.Kennedy R.Pottier |
Clinical application of ALA. |
