Table 2. First generation photosensitizers and their targets.

Photosensitizer	Wavelength	Targets	Authors	Year
Hematoporphyrin derivative (HpD)	630 nm	100 patients with malignant mesothelioma	Clarke CP, Knight SR, Daniel FJ, et al. [89].	2006
		Patients with high grade glioma	Stylli SS, Kaye AH, MacGregor L, et al. [90].	2005
		Brain tumor tissue sample	Stylli SS, Howes M, MacGregor L, et al. [11].	2004
		142 patients with advanced gastrointestinal cancers	Jin ML, Yang BQ, Zhang W, et al. [91].	1992
		Patients with subfoveal choroidal neovascularization	Schmidt-Erfurth U, Miller J, Sickenberg M, et al.[92].	1990
Photofrin	630 nm	Mice bearing radiation-induced fibrosarcoma tumors	Qiu H, Kim MM, Penjweini R,et al. [93].	2017
		23 patients with advanced colorectal cancer	Sun BO, Li W, Liu N, et al. [15].	2016
	635 nm	4T1 BALB/c female mice (Breast cancer)	Wang, X., Hu, J., Wang, P., et al. [94].	2015
	625 nm	Male Wistar rats (Oral cancer/dysplasia)	Nauta, J.M., van Leengoed, H.L., Witjes, M.J., et al.[95].	1997
	635 nm	OVCAR3 Nude mice (Ovarian)	Peterson, C.M., Reed, R., Jolles, C.J., et al.[96].	1992