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. 2017 Sep 16;8(46):81679–81685. doi: 10.18632/oncotarget.20955

Table 1. Key microRNAs in lung cancer.

miRNAs Gene targets Biological mechanisms References
miR-494 IGF2BP1 Promotes angiogenesis and decreases cellular proliferation [8, 9]
Let-7 RAS, CDC25A, CDK6, cyclin D, LIN28, MYC, HMGA2, HOXA9, TGFBR1, BCL-XL, MAP4K3 Represses cell proliferation and regulates the cell cycle [4, 13]
miR-155 hexokinase 2, APAf-1 Promotes glucose metabolism, modulates cellular apoptosis and DNA damage response [10, 14]
miR-153 ADAM19, AKT Inhibits the migration and invasion of human non-small cell lung cancer, inhibits proliferation and migration, and promotes the apoptosis of cultured lung cancer cells [11, 12]
miR-101 COX-2, Lin28B, EZH2 Inhibits cell proliferation, inflammation, and dysregulation of the cell cycle [1518]
miR-135b IL-1R1 Mediates the inflammatory response [19]
miR-200 ZEB, E-cadherin, vimentin Promotes EMT [20, 21]
miR-218 Slug/ZEB2, tumor protein D52 Inhibits cell migration, invasion and EMT [22, 23]
miR-487b SUZ12, BMI1, WNT5A, MYC, KRAS Represses the proliferation and invasion of LC cells [24]