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. 2017 Oct 24;7:13862. doi: 10.1038/s41598-017-14383-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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C. amycolatum induces RNase 7 expression in primary keratinocytes and in an organotypic skin equivalent. (a) Treatment of human primary keratinocytes for 22–24 h with living C. amycolatum induced RNase7 gene expression as measured by real-time PCR. (b) ELISA analyses revealed also an increased secretion of RNase 7 by keratinocytes upon stimulation with living C. amycolatum. Shown are means ± s.e.m. of six stimulations (**p < 0.01, Student’s t test). (c,d) An organotypic skin equivalent was treated with living C. amycolatum for 22–24 h. (c) RNase7 gene expression was analyzed by real-time PCR and (d) RNase 7 secretion was determined by a RNase 7-specific ELISA of the culture medium. Shown are means ± s.e.m. of four different skin equivalents (*p < 0.05, Student’s t test).