Table 3. Comparison of published AL exposure in the context of NVP-based ART therapy.
This study | Kredo et al. 2011 | Maganda et al. 2014 | Kibwika et al, 2012 | Parikh et al. 2015 | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
median change % | geomean change % | P value | median change% | p value | median change% | p value | median change% | p value | geomean change% | p value | |
ARM_Cmax | -54 | -50 | 0.07 | -56 | 0.015 | -61 | <0.01 | -68 | <0.01 | ||
ARM_AUC | -48 | -46 | 0.08 | -55 | 0.12 | -72 | <0.01 | -68 | <0.01 | ||
DHA_Cmax | -38 | -36 | 0.01 | -14 | 0.08 | -45 | <0.01 | -23 | 0.37 | ||
DHA_AUC | -18 | -22 | 0.06 | -25 | 0.01 | -37 | <0.01 | -11 | 0.69 | ||
LR_Cmax | 106 | 95 | <0.001 | 24 | 0.06 | -24 | 0.6 | -47 | 0.07 | ||
LR_AUC | 206 | 123 | <0.001 | 56 | 0.001 | -21 | 0.4 | -49 | 0.048 | ||
LR_Cday7 | 116 | 172 | <0.001 | 85 | <0.001 | 16 | 0.063 | -9.6 | 0.2 |