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. 2017 Oct 24;12(10):e0186589. doi: 10.1371/journal.pone.0186589

Table 3. Comparison of published AL exposure in the context of NVP-based ART therapy.

  This study Kredo et al. 2011 Maganda et al. 2014 Kibwika et al, 2012 Parikh et al. 2015
  median change % geomean change % P value median change% p value median change% p value median change% p value geomean change% p value
ARM_Cmax -54 -50 0.07 -56 0.015 -61 <0.01 -68 <0.01
ARM_AUC -48 -46 0.08 -55 0.12 -72 <0.01 -68 <0.01
DHA_Cmax -38 -36 0.01 -14 0.08 -45 <0.01 -23 0.37
DHA_AUC -18 -22 0.06 -25 0.01 -37 <0.01 -11 0.69
LR_Cmax 106 95 <0.001 24 0.06 -24 0.6 -47 0.07
LR_AUC 206 123 <0.001 56 0.001 -21 0.4 -49 0.048
LR_Cday7 116 172 <0.001 85 <0.001 16 0.063 -9.6 0.2