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. 2017 May 31;7(5):335–404. doi: 10.1007/s13659-017-0135-9

Table 4.

Synthetic compounds with anti-aging activities

CAS Chemicals Structure Anti-aging activity and proposed anti-aging mechanism
With anti-aging activities in two aging models
 51-28-5 2,4-Dinitrophenol graphic file with name 13659_2017_135_Figik_HTML.gif In mice: 7.0% increase in mean lifespan; enhancing tissue respiratory rates, improving serological glucose, triglyceride and insulin levels, decreasing reactive oxygen species levels and tissue DNA and protein oxidation, as well as reduced body weight [348]
In D. melanogaster: 20.0% increase in mean lifespan; increasing the rate of oxygen consumption by isolated mitochondria and tissue homogenates, decreasing the activity of alcohol dehydrogenase [349]
With anti-aging activities in mice
 91-53-2 Ethoxyquin graphic file with name 13659_2017_135_Figil_HTML.gif In C3H mice: 18.0% increase in mean lifespan in male, 20.0% in female and antioxidant [350]
 1001645-58-4 SRT1720 graphic file with name 13659_2017_135_Figim_HTML.gif In mice: 9.0% increase in mean lifespan and inhibiting proinflammatory gene expression [351]
With anti-aging activities in Drosophila melanogaster
 307297-39-8 Epitalon graphic file with name 13659_2017_135_Figin_HTML.gif 17.0% increase in mean lifespan and antioxidatant [352]
 34592-47-7 Thiazolidine carboxylic acid graphic file with name 13659_2017_135_Figio_HTML.gif 31.0% increase in mean lifespan and antioxidatant [353]
 133550-30-8 AG-490 graphic file with name 13659_2017_135_Figip_HTML.gif 18.0% increase in mean lifespan and activating ERK1/2 signaling [354]
 4431-00-9 Aurintri-carboxylic acid graphic file with name 13659_2017_135_Figiq_HTML.gif 15.0% increase in mean lifespan and regulating p66ShcA [355]
 91742-10-8 HA-1004 (dihydrochloride) graphic file with name 13659_2017_135_Figir_HTML.gif 18.0% increase in mean lifespan and inhibiting protein kinase [354]
 103745-39-7 HA-1077 (Fasudil) graphic file with name 13659_2017_135_Figis_HTML.gif 15.0% increase in mean lifespan and inhibiting protein kinase [354]
 5108-96-3 Pyrrolidine dithiocarbamate graphic file with name 13659_2017_135_Figit_HTML.gif 16.0% increase in mean lifespan and inhibiting NF-κB [356]
With anti-aging activities in Caenorhabditis elegans
 75529-73-6 Amperozide hydrochloride graphic file with name 13659_2017_135_Figiu_HTML.gif 38.0% increase in mean lifespan and antioxidatant [176]
 193611-72-2 BRL 15572 graphic file with name 13659_2017_135_Figiv_HTML.gif 10.0% increase in mean lifespan and antioxidatant [176]
 433695-36-4 BRL 50481 graphic file with name 13659_2017_135_Figiw_HTML.gif 18.0% increase in mean lifespan and antioxidatant [176]
 145915-58-8 DAPH (4,5-dianilino-phthalimide) graphic file with name 13659_2017_135_Figix_HTML.gif 15.0% increase in mean lifespan and antioxidatant [176]
 53177-12-1 EUK-8 graphic file with name 13659_2017_135_Figiy_HTML.gif 54.0% increase in mean lifespan and antioxidant [357]
 81065-76-1 EUK-134 graphic file with name 13659_2017_135_Figiz_HTML.gif 54.0% increase in mean lifespan and antioxidant [357]
 98299-40-2 Hexahydro-sila-diphenidol graphic file with name 13659_2017_135_Figja_HTML.gif 15.0% increase in mean lifespan and antioxidatant [176]
 142273-20-9 Kenpaullone graphic file with name 13659_2017_135_Figjb_HTML.gif 27.0% increase in mean lifespan and antioxidatant [176]
 83846-83-7 Ketanserin tartrate graphic file with name 13659_2017_135_Figjc_HTML.gif 13.0% increase in mean lifespan and antioxidatant [176]
 13614-98-7 Minocycline hydrochloride graphic file with name 13659_2017_135_Figjd_HTML.gif 43.0% increase in mean lifespan and antioxidatant [176]
 66104-23-2 Pergolide methanesulfonate graphic file with name 13659_2017_135_Figje_HTML.gif 37.0% increase in mean lifespan and antioxidatant [176]
 497-27-8 4-Phenyl-3-Furoxan-carbonitrile graphic file with name 13659_2017_135_Figjf_HTML.gif 30.0% increase in mean lifespan and antioxidatant [176]
 58-33-3 Promethazine hydrochloride graphic file with name 13659_2017_135_Figjg_HTML.gif 32.0% increase in mean lifespan and antioxidatant [176]
 7681-67-6 Propionyl-promazine hydrochloride graphic file with name 13659_2017_135_Figjh_HTML.gif 20.0% increase in mean lifespan and antioxidatant [176]
Trans-3,5-dimethoxy-4-fluoro-4-hydroxystilbene graphic file with name 13659_2017_135_Figji_HTML.gif 3.6% increase in mean lifespan and antioxidatant [358]
Trans-2,4,5-trihydroxystilbene graphic file with name 13659_2017_135_Figjj_HTML.gif 5.4% increase in mean lifespan and antioxidatant [358]
 78416-81-6 Trequinsin hydrochloride graphic file with name 13659_2017_135_Figjk_HTML.gif 27.0% increase in mean lifespan and antioxidatant [176]
 274-85-1 1,2,4-Triazolo[1,5-a]pyridine graphic file with name 13659_2017_135_Figjl_HTML.gif 12.0% increase in mean lifespan and antioxidant [359]
 138090-06-9 (R,R)-cis-Diethyl- tetrahydro-2,8-chrysenediol graphic file with name 13659_2017_135_Figjm_HTML.gif 7.0% increase in mean lifespan and increasing stress resistance [176]
 2390-54-7 Thioflavin T graphic file with name 13659_2017_135_Figjn_HTML.gif 60.0% increase in mean lifespan and regulating HSF-1 and SKN-1 [360]
 175698-05-2 3,3-Diethyl-2-pyrrolidinone graphic file with name 13659_2017_135_Figjo_HTML.gif 31.0% increase in mean lifespan and regulating neuromuscular activity [336]
 631-64-1 Dibromoacetic acid graphic file with name 13659_2017_135_Figjp_HTML.gif 15.0% increase in mean lifespan and inducing protective stress response [225]
 82-76-8 N-Phenyl periacid(ANSA) graphic file with name 13659_2017_135_Figjq_HTML.gif 22.7% increase in mean lifespan and increasing aging related pharyngeal pumping rate [63]
 51314-51-3 Benzimidazole derivative M084 graphic file with name 13659_2017_135_Figjr_HTML.gif 19.10% increase in mean lifespan; regulating IIS pathway, AMPK, SIR-2.1, SKN-1, mitochondrial electron transport chain, and mitochondrial unfolded protein response [361–364]
With anti-aging activities in Asplanchna brightwelli
 111-17-1 3,3′-Thiodipropionic acid graphic file with name 13659_2017_135_Figjs_HTML.gif 16.0% increase in mean lifespan and increasing lipid peroxides [365]