Table 2.
Total serum histones, leukocyte count, platelets, serum enzyme activities, and lactate and total CO2 concentrations, pH, and clotting in ten non-surviving and six surviving dogs with naturally occurring heatstroke
| Analyte (reference interval; units) | Survivors (n = 6) median (range) | Non-survivors (n = 10) median (range) | P value1 |
|---|---|---|---|
| Serum histones (ng/mL) | 8.16 (1.0–19) | 21.4 (4.2–40) | 0.0492 |
| White blood cell count (6–10 × 103/μL) | 10.5 (6.8–19.1) | 18.5 (6.7–35.0) | 0.05 |
| Hematocrit (35–50%) | 62 (50–72) | 57 (23–65) | 0.28 |
| Platelets (>143 × 103) | 93 (57–170) | 115 (61–431) | 0.36 |
| Lactate (0–1.8 mmol/L) | 2.2 (0.9–9.9) | 2.9 (1.6–8.9) | 0.54 |
| Aspartate transaminase (14–80 U/L) | 416 (2223–1623) | 3293 (104–6153) | 0.62 |
| Alanine aminotransferase (19–67; U/L) | 130 (86–182) | 522 (44–1929) | 0.92 |
| Creatine kinase (20–160 U/L) | 9333 (461–40,000) | 40,000 (684–54,558) | 0.69 |
| γ-glutamyl transpeptidase (0–6 U/L) | 1.5 (1.7–6.5) | 12.7 (6.1–26.3) | 0.039 |
| Alkaline phosphatase (13–190 U/L) | 77 (28–100) | 202 (15–254) | 0.049 |
| Creatinine (0.5–1.2 mg/dL) | 1.5 (1.1–1.8) | 1.6 (0.6–2.8) | 0.71 |
| Urea (10–45 mg/dL) | 47 (31–68) | 59 (6–83) | 0.6 |
| Prothrombin time (6.0–8.4 s) | 12.6 (6.9–30.0) | 15.8 (7–27) | 0.5 |
| aPTT (11–17.4 s)3 | 30.6 (12–100) | 43.0 (21–100) | 0.6 |
| pH (7.35–7.45) | 7.38 (7.22—7.4) | 7.26 (7.08–7.38) | 0.07 |
| Bicarbonate (18–22 mmol/L) | 16.5 (15.1–21.1) | 13.2 (9.9–17.2) | 0.04 |
| Total CO2 (22–26 mmol/L) | 9.2 (9.0–13.7) | 10.7 (5.2–16.6) | 0.7 |
aMedian values compared using the Mann-Whitney non-parametric test
bLogarithmic transformation was performed, distribution was assessed by Q-Q plot, and Student’s t test was used to compare sHs concentration between survivors and non-survivors
cActivated partial thromboplastin time