Table 1.
Clinical features of study subjects.
| Subject/sex | Age (years) | Affected body part | Duration (years) | HAM-A | HAM-D | MINI | Medications | |
|---|---|---|---|---|---|---|---|---|
| Functional tremor | 1 F | 52 | BUE, BLE | 18 | 15 | 17 | MDD (P) | Duloxetine, alprazolam, primidone, amitriptyline, propranolol |
| 2 F | 50 | BUE | 2 | 17 | 17 | None | Milnacipran | |
| 3 F | 46 | LUE, head | 11 | 8 | 15 | NGSP, OCD (C) | Clonazepam | |
| 4 F | 56 | BUE | 3 | 27 | 17 | None | Duloxetine, modafinil, methylphenidate, imipramine, lorazepam, gabapentin | |
| 5 M | 40 | LUE > RUE | 20 | 6 | 19 | None | Carbamazepine, citalopram | |
| 6 F | 64 | RUE | 11 | 0 | 5 | MDD (C) | None | |
| 7 F | 49 | BUE, BLE | 21 | 15 | 19 | MDD, PD-Ag, GSP, OCD, PTSD, GAD (C) | Risperidone, clonazepam, propranolol | |
| 8 F | 60 | BUE | 3 | 3 | 2 | None | Lorazepam, valproate, sertraline | |
| 9 F | 34 | BUE, head | 3 | 2 | 16 | PD-Ag, GSP, OCD, PTSD, Hypomania (C) | Duloxetine | |
| 10 F | 55 | BUE | 4 | 20 | 11 | Agoraphobia (C) | Duloxetine, trazodone, alprazolam | |
| 11 F | 63 | Head, trunk, BLE | 3.5 | 1 | 3 | None | None | |
| 12 F | 45 | BUE | 1 | 3 | 5 | None | None | |
| 13 F | 58 | RUE, stuttering | 2 | 28 | 20 | MDD, PD, PTSD, MDSP (C) | Citalopram, quetiapine, clonazepam, lamotrigine, sertraline | |
| 14 F | 38 | RUE, RLE, eye | 4 | 7 | 10 | None | Citalopram, diazepam, propranolol, topiramate | |
| 15 F | 38 | BUE, head | 4 | 28 | 26 | MDD, PD-Ag, PTSD, GAD (C) | Cyclobenzaprine, duloxetine | |
| 16 F | 38 | BUE | 1.2 | 3 | 3 | None | Clonazepam | |
| 17 F | 43 | BLE, stuttering | 6 | 46 | 43 | MDD, GAD, PD, PTSD (C) | Paroxetine | |
| 18 M | 27 | RUE | 1 | 0 | 0 | None | Amitriptyline | |
| 19 M | 44 | BLE > BUE, head | 3.5 | 24 | 18 | PD, PTSD (P) | Gabapentin, fluoxetine, clonazepam, baclofen | |
| 20 F | 66 | LUE, BLE | 1 | 22 | 11 | None | None | |
| 21 M | 65 | Head, RUE, LUE | 1.5 | 5 | 7 | None | None | |
| 22 F | 49 | BUE | 1 | 27 | 29 | MDD, PD-Ag, PTSD (C) | Clonazepam, diazepam, venlafaxine | |
| 23 F | 52 | BUE, BLE | 0.5 | 23 | 32 | MDD, GSP (C) | Valproate, gabapentin, alprazolam, baclofen | |
| 24 F | 75 | RUE, RLE | 1 | 13 | 10 | None | Escitalopram | |
| 25 F | 58 | Head, BUE | 1.5 | 5 | 9 | None | Primidone, propanolol, trazodone | |
| 26 F | 63 | RUE, RLE | 2.5 | 14 | 15 | PD-Ag, OCD (C) | None | |
| 27 F | 53 | Face, head, BUE, BLE | 1 | 32 | 23 | MDD, PD, GSP (C) alcohol dependence (P) | Clonazepam, desvenlafaxine, lamotrigine, lithium carbonate | |
| Essential tremor | 1 | 68 | BUE | 9 | 0 | 1 | None | Propranolol, hydrocodone, ropinirole |
| 2 | 46 | BUE | 30 | 0 | 0 | None | Propranolol, bupropion, duloxetine | |
| 3 | 56 | BUE | 40 | 0 | 0 | None | Atenolol | |
| 4 | 56 | RUE | 1.5 | 5 | 9 | None | Zolpidem, propranolol, amitriptyline | |
| 5 | 47 | BUE | 40 | 0 | 1 | None | Amitriptyline, primidone | |
| 6 | 64 | RUE > LUE | 53 | 0 | 0 | None | Primidone, gabapentin, propranolol, cyclobenzaprine | |
| 7 | 55 | BUE, neck | 35 | 23 | 20 | MDD, PD | Propranolol, quetiapine, lorazepam, lamotrigine, desvenlafaxine, flurazepam | |
| 8 | 64 | BUE | 20 | 0 | 0 | None | Unknown | |
| 9 | 61 | BUE | 49 | 7 | 3 | None | Citalopram, primidone | |
| 10 | 74 | BUE | 14 | 4 | 4 | None | Diazepam | |
| 11 | 75 | BUE, voice | 20 | 5 | 2 | None | Citalopram, clonazepam, primidone, topiramate | |
| 12 | 50 | LUE | 20 | 7 | 4 | GAD | Escitalopram, trazodone | |
| 13 | 61 | BUE | 21 | 0 | 0 | None | Propranolol | |
| 14 | 69 | BUE | 50 | 0 | 1 | None | Zolpidem | |
| 15 | 73 | BUE, head | 20 | 0 | 0 | None | Propranolol | |
| 16 | 68 | LUE, head | 45 | 0 | 0 | None | Unknown |
HAM-D: 17-item Hamilton Depression Rating Scale; HAM-A: 14-item Hamilton Anxiety Rating Scale; MINI: Mini International Neuropsychiatric Interview to screen for axis I DSM-IV and ICD-10 psychiatric disorders; Ag: agoraphobia; OCD: obsessive-compulsive disorder; GAD: generalized anxiety disorder; GSP: generalized social phobia; MDD: major depression; MDSP: Mood Disorder with psychotic features; NGSP: non-generalized social phobia; PD: panic disorder; PTSD: post-traumatic stress disorder. RUE: right upper extremity; LUE: left upper extremity; RLE: right lower extremity; LLE: left lower extremity; RH: right hand; LH: left hand; RF: right foot; LF: left foot; B, bilateral; (C): current; (P): past.