Table 1.

Symbols and GO Terms of Genes Showing Consistent Dysregulation in Trisomy 18 and Trisomy 21

Gene	GO annotations	p value T18	logFC T18	p value T21	logFC T21
OTUD5	GO:0004843(thiol-dependent ubiquitin-specific protease activity)|GO:0061578(Lys63-specific deubiquitinase activity)|GO:0101005 (ubiquitinyl hydrolase activity)|GO:1990380 (Lys48-specific deubiquitinase activity)|GO:0016579(protein deubiquitination)|GO:0032496(response to lipopolysaccharide)	0.013	−0.34	0.023	−0.594
ADAMTSL1	(GO:0004222(metalloendopeptidase activity)|GO:0008233 (peptidase activity)|GO:0008270 (zinc ion binding)|GO:0006508(proteolysis)	0.010	0.622	0.018	0.449
TADA2A	(GO:0003677(DNA binding)|GO:0005634(nucleus)|GO:0006355 (regulation of transcription, DNA-templated)|GO:0035065 (regulation of histone acetylation)	0.008	0.354	0.038	0.062
PPID	GO:0003755(peptidyl-prolyl cis-trans isomerase activity)|GO:0000413(protein peptidy-prolyl isomerization)|GO:0006457 (protein folding)	0.012	0.49	0.039	0.418
PIAS2	GO:0019789(SUMO transferase activity)|GO:0016925(protein sumoylation)	0.007	0.942	0.019	0.445
MAPRE2	GO:0008017 (microtubule binding)|GO:0005874(microtubule)	0.009	0.47	0.029	0.328

All genes were upregulated in both trisomies, except for OTUD5, which was downregulated. T18, trisomy 18 and T21, trisomy 21. The p values were adjusted using the Benjamini–Hochberg correction; logFC, log fold change. The GO annotations (function, process or cellular component) were searched using EMBL-EBI QuickGO (www.ebi.ac.uk).

GO.