FIG. 3.

mTOR signaling is disrupted in synaptosomes from ADL and YA APP/PS1 mice. Levels of pmTOR (Ser2448); (A) were decreased in synaptosomes from ADL and YA APP/PS1 mice as compared with those from age-matched WT controls. Similar decreases in phosphorylated forms of two mTOR substrates: pS6K at Thr389 (B) and p4EBP1 at Thr46/47 (C), were observed in synaptosomes of APP/PS1 mice at all ages examined. Values are mean ± SEM (n = 6 mice) and * denotes values significantly different from corresponding controls (p < 0.05). See also Supplementary Fig. S2. pmTOR, phosphorylated mTOR.