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. 2017 Oct 24;12(10):e0186586. doi: 10.1371/journal.pone.0186586

Fig 3. DualAG induced elevation of LDL receptor (LDLr) expression in livers of DIO mice.

Fig 3

Mice were fasted for 2hrs followed by injection of vehicle, Liraglutide (25nmol/kg) or DualAG (25nmol/kg). A. Hepatic protein expression of LDLr and Pcsk9 after 6 hrs of treatment injection, as determined by western blots. B. Blot intensity for LDLr and Pcsk9 was quantified by ImageJ and plotted after normalizing to tubulin expression. C. Hepatic LDLr protein expression after 2, 3, and 6 hrs of treatment injection. D. Blot quantification for LDLr at 2, 3, and 6 hrs after treatment injection. E. Relative mRNA expression of LDLr in liver. F. Relative mRNA expression of Pcsk9 in liver. G. Plasma apolipoprotein (Apo) B100 levels over the course of 6 hrs after injection of DualAG. H. Plasma ApoB48 levels over the course of 6 hrs after injection of DualAG]. I. Plasma levels of total ApoB in vehicle and Liraglutide treated groups at 6 hrs after injection.