Table 1.

Treatment regimens recommended for patients with heart failure with a reduced ejection fraction

Scenario	NYHA class	Minimum requirement
Strict pattern	NYHA I	ACE inhibitor or ARB
	NYHA II	(ACE inhibitor or ARB) and β-blocker and diuretic
	NYHA III–IV	(ACE inhibitor or ARB) and β-blocker and diuretic and MRA (spironolactone or eplerenone)
Less strict pattern	NYHA I	ACE inhibitor or ARB
	NYHA II	(ACE inhibitor or ARB) and β-blocker and diuretic
	NYHA III–IV	(ACE inhibitor or ARB) and β-blocker and diuretic

ACE angiotensin-converting enzyme, ARB angiotensin II receptor blocker, MRA mineralocorticoid receptor antagonist, NYHA New York Heart Association