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. 2017 Oct 24;7:13867. doi: 10.1038/s41598-017-10131-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The regulatory network of transcription factors (TFs) and their differentially expressed target genes (TG) as determined by TF-TG regulatory relationships from CellNet. (A) The TF-TG regulatory network of H9c2 cells treated with H₂O₂ in comparison to the control cells. Blue indicates TFs changed only in the model group compared to the control group. (B) The TF-TG regulatory network of H9c2 cells pre-treated with YXS in comparison to the model group. Yellow indicates TFs altered only in the YXS-treated cells. Pink indicates TFs that were co-regulated in both the model group compared with the control and the YXS group compared with the model group. A star marker was added to indicate TFs or targets that are involved in apoptotic processes.