Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Oct 24;7:13901. doi: 10.1038/s41598-017-14472-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Effects of PKA inhibition and activation on cocaine-induced changes in DA transmission. Co-application of 10 μM cocaine (Co) with either a PKA activator (cAMP) or an inhibitor (KT 5720; KT) resulted in a significant increase in DA release (a). KT also caused a significant increase in peak DA in comparison to baseline values when perfused alone (a). Superfusing cocaine with either 10 μM cAMP or 0.1 μM KT significantly attenuated cocaine-induced increases in tau (b). Perfusion of the lowest concentration of KT, which had no effect on DA clearance in its own right, in the presence of both 5 μM RO5256390 and 10 μM cocaine, had no effect on RO5256390’s ability to attenuate cocaine-induced increases in tau (d). (*p < 0.05, **p < 0.01 vs baseline; ^#p < 0.05, ^##p < 0.01 vs cocaine values; n = 5–19).