Table 3.

Factors associated with IE binding to endothelial receptors.

Receptor	HbACa		HbASa		Ageb		Blood group Ac		Blood group ABc		Blood group Bc		Severe malariad
	Coefficient (SE)	P value	Coefficient (SE)	P value	Coefficient (SE)	P value	Coefficient (SE)	P value	Coefficient (SE)	P value	Coefficient (SE)	P value	Coefficient (SE)	P value
CD36	−86.49 (20.12)	<0.0001	−62.53 (26.76)	0.02	1.85 (0.42)	<0.0001	12.424 (15.73)	0.43	−13.41 (26.48)	0.61	13.40 (15.39)	0.38	−16.52 (43.14)	0.7
TSP	−0.96 (3.43)	0.78	−1.48 (4.56)	0.75	0.13 (0.07)	0.07	−5.34 (2.67)	0.046	−7.71 (4.50)	0.09	−4.81 (2.64)	0.07	3.70 (7.68)	0.6
ICAM-1	−15.23 (5.51)	0.006	0.65 (7.35)	0.93	0.30 (0.11)	0.01	−25.29 (4.31)	<0.0001	−28.18 (7.25)	<0.0001	−22.16 (4.22)	<0.0001	7.56 (11.81)	0.5
E-selectin	−6.83 (2.71)	0.012	−0.74 (3.61)	0.84	0.04 (0.06)	0.5	−3.65 (2.12)	0.09	−6.46 (3.58)	0.07	−5.65 (2.08)	0.007	3.69 (5.82)	0.5
P-Selectin	−8.50 (3.06)	0.006	−1.52 (4.06)	0.71	0.06 (0.06)	0.4	−5.07 (2.39)	0.03	−2.29 (4.03)	0.57	−6.09 (2.34)	0.009	0.97 (6.56)	0.8
PECAM-1	−6.23 (2.16)	0.004	−3.06 (2.78)	0.27	0.02 (0.05)	0.6	1.93 (1.66)	0.24	0.62 (2.69)	0.82	1.74 (1.62)	0.28	1.80 (4.41)	0.7
VCAM-1	−1.32 (1.53)	0.39	−1.60 (2.04)	0.43	0.05 (0.03)	0.09	−1.52 (1.20)	0.20	−1.28 (2.02)	0.53	−1.53 (1.17)	0.19	−2.34 (3.29)	0.5
CSA	−0.93 (0.78)	0.23	0.81 (1.03)	0.43	0.04 (0.02)	0.02	−0.99 (0.61)	0.10	−1.38 (1.02)	0.18	−1.08 (0.59)	0.07	0.78 (1.66)	0.6
EPCR	3.45 (1.51)	0.02	−0.69 (2.14)	0.75	0.008 (0.03)	0.80	−2.23 (1.24)	0.07	−0.74 (2.13)	0.73	−1.16 (1.14)	0.31	−2.72 (3.35)	0.4
Integrin α5β1	−8.37 (2.23)	<0.0001	−3.00 (2.98)	0.32	0.18 (0.05)	<0.0001	−2.73 (1.74)	0.12	−5.39 (2.92)	0.07	−4.67 (1.70)	0.006	1.77 (4.75)	0.7
Vitronectin	−0.90 (0.55)	0.10	−0.04 (0.73)	0.96	0.02 (0.01)	0.09	−0.10 (0.43)	0.80	−0.71 (0.71)	0.32	−0.46 (0.42)	0.28	−0.86 (1.21)	0.5
Cellular fibronectin	−0.68 (1.45)	0.64	−1.52 (1.92)	0.54	−0.007 (0.03)	0.82	−2.43 (1.13)	0.03	−2.60 (1.90)	0.17	−1.42 (1.11)	0.20	0.70 (3.10)	0.8
Laminin	1.00 (1.02)	0.34	0.20 (1.35)	0.88	−0.007 (0.02)	0.73	−1.45 (0.79)	0.07	−2.45 (1.34)	0.07	−1.10 (0.78)	0.15	2.10 (2.18)	0.3
Integrin α3β1	−7.37 (2.42)	0.003	−0.52 (3.21)	0.88	0.14 (0.05)	0.005	−3.17 (1.89)	0.09	−4.90 (3.18)	0.12	−3.95 (1.85)	0.03	3.14 (5.18)	0.5
Integrin αvβ3	−12.72 (4.86)	0.009	−1.24 (6.43)	0.85	0.18 (0.10)	0.07	−5.70 (3.79)	0.13	−6.16 (6.36)	0.33	−5.98 (3.71)	0.11	−3.16 (10.32)	0.8
JAM-A	−0.72 (0.41)	0.08	0.61 (0.54)	0.26	0.02 (0.008)	0.008	−0.27 (0.32)	0.39	0.015 (0.53)	0.98	−0.03 (0.31)	0.92	−0.27 (0.90)	0.8
JAM-B	−0.70 (4.06)	0.86	11.98 (5.64)	0.03	−0.41 (0.08)	<0.0001	−2.60 (3.18)	0.41	−4.03 (5.37)	0.45	1.61 (3.10)	0.60	−3.44 (8.60)	0.7
VE-cadherin	−5.70 (3.56)	0.11	5.06 (4.68)	0.28	0.10 (0.07)	0.15	−6.14 (2.76)	0.026	−4.60 (4.60)	0.32	0.81 (2.72)	0.77	−3.14 (7.79)	0.7
ICAM-2	−7.30 (2.98)	0.01	5.69 (3.94)	0.15	0.17 (0.06)	0.005	−3.39 (2.32)	0.15	−2.31 (3.90)	0.55	0.21 (2.27)	0.93	−2.19 (6.33)	0.7

P values of 0.0026 or less are considered significant. Models were adjusted for parasite density in the assay.

^aHbAC and HbAS: Average change in binding level (IE count) compared to samples from children with HbAA.

^bAge: Average change in binding level (IE count) for an increase of 1 month in age.

^cBlood groups A, AB and B: Average change in binding level (IE count) compared to samples from children with blood group O.

^dSevere malaria: Average change in binding level (IE count) compared to samples from children with non-severe malaria.