Table 1.

Summary of the meta-analyses of RCT assessing the efficacy of GnRHa given before and during chemotherapy in cancer patients.

Reference	No. of patients included	Patient population	Endpoint
Pro
Lambertini, 2015	1231	BC	POF, PR
Shen, 2015	1062	BC	POF, PR
Del Mastro, 2014	765	BC, HL, ovarian cancer	POF
Sun, 2014	621	BC, HL, ovarian cancer	POF
Yang, 2013	528	BC	Resumption of menses, spontaneous ovulation, PR
Wang, 2013	677	BC	Resumption of menses
Bedaiwy, 2011	340	BC, HL, ovarian cancer	Resumption of menses, spontaneous ovulation
Chen, 2011		Various	Resumption of menses, spontaneous ovulation, PR
Munhoz, 2016	856	BC	Resumption of regular menses, PR
Contra
Elgindy, 2015	907	Various	Resumption of menstruation, ovarian reserve, PR

BC, breast cancer; HL, Hodgkin lymphoma; POF, premature ovarian failure; PR, pregnancy rate; RCT, randomized clinical trials.