Table 5.

Different GnRHa protocols used in the studies that assessed its potential benefit before/during high-dose chemotherapy in preserving normal gonadal function and fertility in HSCT female recipients.

Study	GnRHa	Dose	Timing
Blumenfeld, 2008, 2012	Triptorelin	A monthly depot injection of 3.75 mg	10–14 days before any gonadotoxic therapy and monthly during chemotherapy
Cheng, 2011	Leuprolide	22.5 mg in a 3-month depot i.m. injection	2 months prior to HSCT
Phelan, 2016	Leuprolide	Long-acting 11.25 mg i.m. once + short-acting 0.2 mg s.c. daily for 14 days	30 days prior to initiation of the HSCT conditioning regimen
Demeestere, 2013, 2016	Triptorelin	11.25 mg every 12 weeks in addition to norethisterone acetate at 5 mg once per day	10 days before the start of chemotherapy if possible