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. 2017 Oct 24;7:13936. doi: 10.1038/s41598-017-13698-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Activity in 3D cell cultures. (A) Spheroids (2.5 × 10³ cells/well) were treated for 72 h with increasing concentrations of tested compounds. The growth inhibitory effect was evaluated by means of APH test. IC₅₀ values were calculated from the dose-survival curves by four parameter logistic model (P < 0.05). SD = standard deviation. (B) Representative images (10x) of HCT-15 3D culture: a = controls; b = spheroids treated with IC₅₀ concentrations of HydroCuP for 24 h; c = spheroids treated with IC₅₀ concentrations of HydroCuP for 48 h.