Table 1.
Summary comparing volumetric and functional parameters between control animals (Ctrl), animals with pulmonary regurgitation (PR) and animals after percutaneous pulmonary valve replacement (PPVR)
| Control | PR | PPVR | p Ctrl v PR | p PR v PPVR | p Ctrl v PPVR | |
|---|---|---|---|---|---|---|
| n | 8 | 12 | 6 | |||
| PR % | 1.3% ± 0.4% | 42.9% ± 2.7% | 1.0% ± 0.3% | <0.0001 | <0.0001 | 0.5540 |
| Weight basline kga | 13.5 ± 0.5 | 13.9 ± 0.8 | 14.9 ± 0.7 | 0.6615 | 0.3858 | 0.1345 |
| Weight imaging kga | 54.9 ± 3.7 | 48.8 ± 4.7 | 76.5 ± 5.9 | 0.3302 | 0.0041 | 0.0133 |
| LV | ||||||
| LVEDV mL | 106 ± 7 | 92 ± 6 | 137 ± 12 | 0.1244 | 0.0111 | 0.0606 |
| LVEDVi % of THV | 21.6% ± 0.5% | 14.7% ± 0.9% | 18.1% ± 0.5% | <0.0001 | 0.0037 | 0.0002 |
| LVESV mL | 45 ± 4 | 40 ± 3 | 49 ± 4 | 0.3449 | 0.0797 | 0.4411 |
| LVESVi % of THV | 9.0% ± 0.4% | 6.4% ± 0.4% | 6.6% ± 0.4% | 0.0005 | 0.7188 | 0.0022 |
| LVSV mL | 62 ± 3 | 52 ± 4 | 87 ± 9 | 0.0612 | 0.0087 | 0.0363 |
| LVEF % | 58.4% ± 1.7% | 56.4% ± 1.4% | 63.2% ± 2.1% | 0.3736 | 0.0253 | 0.1124 |
| Longitudinal % | 70.5% ± 2.1% | 89.6% ± 4.0% | 72.3% ± 2.0% | 0.0006 | 0.0014 | 0.5394 |
| Radial % | 23.3% ± 1.3% | 11.7% ± 3.6% | 21.0% ± 2.6% | 0.0097 | 0.0555 | 0.4543 |
| Lateral % | 20.3% ± 1.5% | 37.0% ± 3.9% | 22.6% ± 3.1% | 0.0015 | 0.0111 | 0.5200 |
| Septal % | 3.0% ± 1.8% | −25.4% ± 3.5% | −1.7% ± 2.8% | <0.0001 | 0.0001 | 0.2025 |
| RV | ||||||
| RVEDV mL | 105 ± 8 | 200 ± 13 | 167 ± 14 | <0.0001 | 0.1069 | 0.0045 |
| RVEDVi % of THV | 21.3% ± 0.3% | 31.4% ± 0.5% | 22.3% ± 1.2% | <0.0001 | 0.0002 | 0.4718 |
| RVESV mL | 40 ± 4 | 81 ± 6 | 63 ± 4 | <0.0001 | 0.0287 | 0.0026 |
| RVESVi % of THV | 8.0% ± 0.4% | 12.7% ± 0.6% | 8.5% ± 0.7% | <0.0001 | 0.0005 | 0.5583 |
| RVSV mL | 66 ± 4 | 120 ± 9 | 104 ± 10 | 0.0032 | 0.0007 | 0.0093 |
| RVEF % | 62.9% ± 1.9% | 59.4% ± 1.7% | 62.0% ± 1.8% | 0.1859 | 0.3171 | 0.7262 |
| RVEF corr % | 27.0% ± 1.8% | |||||
| Longitudinal % | 73.6% ± 3.8% | 60.0% ± 2.6% | 67.0% ± 1.0% | 0.0117 | 0.0235 | 0.1377 |
| Radial % | 31.9% ± 2.5% | 38.0% ± 1.9% | 31.6% ± 2.7% | 0.0721 | 0.0744 | 0.9233 |
| Lateral % | 34.7% ± 2.0% | 27.0% ± 1.8% | 30.4% ± 2.5% | 0.0113 | 0.2921 | 0.1993 |
| Septal % | −2.8% ± 1.7% | 11.0% ± 1.6% | 1.2% ± 2.4% | <0.0001 | 0.0076 | 0.2119 |
LV, left ventricle; RV, right ventricle; EDV, end‐diastolic volume; ESV, end‐systolic volume; EF, ejection fraction; radial, septal + lateral; EF corr., net pulmonary forward flow/EDV; THV, total heart volume. Bold values indicate p<0.05.
a
For PR group: n = 8.