Table 1.
Demographics of subjects
| Never smokers N = 25 | COPDGene N = 2098 | SPIROMICS N = 1117 | p-value (SPIROMICS vs COPDGene) (current and former smokers) | |
|---|---|---|---|---|
| Age (years) | 57.5 (7) | 65.8 (8.9) | 62.7 (9) | < 10−04 |
| Gender Male | 36.0% | 50.9% | 51.9% | 0.6931 |
| Race | ||||
| White | 100.0% | 71.2% | 74.9% | |
| Black | 0.0% | 28.4% | 20.8% | |
| Other | 0.0% | 0.0% | 4.3% | |
| Current Smoker | 0% | 34.7% | 40.5% | 0.0009 |
| BMI (kg/m2) | 25.7 (4.2) | 28.8 (6.3) | 28.2 (5.4) | 0.0028 |
| ATS Smoking, pack-years | 0 (0) | 45.1 (24) | 47.6 (24.7) | 0.0054 |
| FEV1 (% predicted) | 105.5 (12) | 76.1 (25.6) | 76.1 (28.7) | 0.9906 |
| FEV1/FVC | 0.8 (0) | 0.7 (0.2) | 0.6 (0.2) | < 10−04 |
| BODE Index | 0.2 (0.4) | 1.3 (1.7) | 1.5 (2) | 0.0084 |
| SGRQ | 2.7 (3.5) | 23.6 (21.1) | 32 (21.2) | < 10−04 |
| Emphysema (% LAA < −950 HU) | 1 (1.3) | 6.5 (10.2) | 7.3 (10.4) | 0.0386 |
| Chronic Bronchitis (%) | 4% | 15.2% | 20.9% | < 10−04 |
| Duration of participation in study (years) | NA | 6.7 (1.2) | 2.2 (0.9) | < 10−04 |
| Decline in FEV1 (ml/year) | NA | −38.1 (53.4) | −48.5 (144.1) | 0.0416 |
| Exacerbations (#/year) | 0 (0) | 0.3 (0.8) | 0.5 (1.0) | < 10−04 |
| Never Smoker | 100% | 0% | 0% | |
| Spirometry category | ||||
| PRISm | 0% | 10.4% | 0% | |
| Control Smoker | 0% | 41.5% | 49.3% | |
| GOLD 1 | 0% | 9.3% | 7.9% | |
| GOLD 2 | 0% | 20.4% | 17.5% | |
| GOLD 3 | 0% | 12.2% | 18.1% | |
| GOLD 4 | 0% | 5.8% | 7.1% | |
Abbreviations: SGRQ St. George’s Respiratory Questionnaire, HU Hounsfield Unites, BODE Body-mass index, airflow Obstruction, Dyspnea, and Exercise, PRISm preserved ratio, impaired spirometry, GOLD Global Initiative for Chronic Obstructive Lung Disease
P-values are not applicable to race, ever smoking, and spirometry category because these criteria were used as inclusion criteria in one or both studies