Table 2.

Biomarkers associated with FEV₁%

	COPDGene			SPIROMICS			Combined
Biomarker	ß	R2 (adj)	P	ß	R2 (adj)	P	P
Eotaxin	−12.2	0.007	0.0001	−31.3	0.039	< 10−10	< 10−12
CCL26	−1.7	0.000	0.2225	−3.4	0.001	0.1095	0.0679
CCL17	0.1	0.000	0.9383	−3.7	0.001	0.1664	0.3525
IFN-γ	−6.2	0.006	0.0003	−4.5	0.002	0.0881	0.0002
IL10	−4.1	0.003	0.0072	−6.2	0.003	0.0442	0.0013
IL2	−2.8	0.002	0.0426	−7.2	0.007	0.0043	0.0016
IL6	−16.2	0.049	< 10−23	−21.1	0.042	< 10−11	< 10−34
IL8	−4.2	0.002	0.0226	−9.9	0.005	0.0091	0.0008
TNF-α	−7.0	0.006	0.0004	−6.4	0.001	0.1725	0.0003

R² _(adj) is the partial amount of variance explained by the biomarker in models with clinical covariates