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Neutralizing antibody. The neutralizing antibody titer increased significantly following vector instillation for both viruses. However, the magnitude of the increase in AAV1 neutralizing antibodies was considerably lower than that for AAV5, despite the presence of more AAV1 particles in the airways. Data are averages ± SEM; n = 4 samples from four monkeys. Paired t-test; *p < 0.05, p = 0.0193. Measurements from samples taken at necropsy. y-Axis is to the power of 10.
