Table 1.
Ratio of deposition
| NHP ID | Lung | Face/throat | Face mask | Exhaust filter | Idehaler chamber |
|---|---|---|---|---|---|
| RQ8425a | 0.03 | 0.06 | 0.21 | 0.69 | 99.0 |
| RQ8676 | 2.15 | 2.82 | 3.96 | 8.36 | 82.7 |
| RQ8872 | 0.78 | 2.73 | 3.07 | 8.80 | 84.6 |
| RQ8571 | 0.66 | 4.03 | 4.68 | 9.29 | 81.3 |
| Average | 1.20 | 3.19 | 3.90 | 8.81 | 82.89 |
| SD | 0.83 | 0.73 | 0.81 | 0.47 | 1.65 |
Gamma images were acquired with the animal in a prone position. Immediately following each image, the nebulizer components (face mask, exhaust filter, and Idehaler chamber) were imaged. Images were acquired with a 128 × 128 matrix, zoom factor of 1, and as static planar images. Images were analyzed with the ICON software. Radioactivity was determined for each region of interest (ROI) including the lungs, oral/nasal cavity, face mask, exhaust filter, and Idehaler holding chamber. Counts in each ROI were converted to radioactivity through a daily curve, prepared on the dose calibrator. The percentage in each ROI was determined based on the amount consumed by the nebulizer.
Note that most of the technetium remained in the chamber of the inhaler.
NHP, nonhuman primate; SD, standard deviation.