Table 3.
Summary of hematology results
| Sex | ID | NA-S mM | K-S mM | CL-S mM | GLU mg/dL | BUN mg/dL | CRE-S mg/dL | PHOS mg/dL | BILIT mg/dL | ALP IU/L | ALT IU/L | AST IU/L | TP g/dL | ALB g/dL | CA mg/dL | CK IU/L | CHOL mg/dL | GLOBN g/dL | AG ratio | BC ratio |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pretreatment | ||||||||||||||||||||
| Male | RQ8571 | 147 | 3.7 | 109 | 56 | 23 | 0.6 | 4.6 | 0.2 | 446 | 38 | 46 | 7.3 | 4.7 | 9.9 | 575 | 166 | 2.6 | 1.8 | 38 |
| RQ8872 | 152 | 4.5 | 110 | 115 | 18 | 0.8 | 4.3 | 0.2 | 560 | 23 | 35 | 7.3 | 4.9 | 10.8 | 702 | 155 | 2.4 | 2 | 23 | |
| Female | RQ8425 | 146 | 3.7 | 108 | 81 | 24 | 0.7 | 4.8 | 0.1 | 379 | 20 | 26 | 6.7 | 4.5 | 10.3 | 430 | 139 | 2.2 | 2 | 34 |
| RQ8676 | 144 | 3.2 | 107 | 66 | 19 | 0.6 | 3.6 | 0.2 | 260 | 26 | 26 | 6.9 | 4.6 | 10.4 | 556 | 147 | 2.3 | 2 | 32 | |
| Pretreatment | ||||||||||||||||||||
| Male | RQ8571 | 146 | 3.5 | 107 | 61 | 23 | 0.5 | 5.1 | 0.2 | 561 | 25 | 48 | 7.1 | 4.4 | 9.4 | 1078 | 132 | 2.7 | 1.6 | 46 |
| RQ8872 | 149 | 3.9 | 104 | 82 | 19 | 0.9 | 4.6 | 0.3 | 571 | 25 | 36 | 7.4 | 5.1 | 10 | 490 | 171 | 2.3 | 2.2 | 21 | |
| Female | RQ8425 | 144 | 3.4 | 104 | 77 | 23 | 0.7 | 5.9 | 0.2 | 398 | 29 | 35 | 6.9 | 4.5 | 9.5 | 801 | 135 | 2.4 | 1.9 | 33 |
| RQ8676 | 145 | 3.6 | 107 | 43 | 24 | 0.6 | 4.5 | 0.2 | 265 | 44 | 31 | 7.1 | 4.5 | 9.6 | 764 | 126 | 2.6 | 1.7 | 40 | |
| Post treatment | ||||||||||||||||||||
| Male | RQ8571 | 149 | 3.8 | 113 | 63 | 20 | 0.5 | 4.7 | 0.3 | 632 | 24 | 37 | 7.3 | 4.5 | 9.4 | 234 | 126 | 2.8 | 1.6 | 40 |
| RQ8872 | 146 | 3.1 | 104 | 111 | 17 | 0.8 | 5.1 | 0.3 | 441 | 24 | 32 | 7.7 | 5.2 | 9.9 | 425 | 157 | 2.5 | 2.1 | 21 | |
| Female | RQ8425 | 144 | 3.4 | 104 | 58 | 23 | 0.7 | 5.9 | 0.2 | 369 | 30 | 46 | 7 | 4.5 | 9.2 | 465 | 147 | 2.5 | 1.8 | 33 |
| RQ8676 | 143 | 3.1 | 106 | 51 | 21 | 0.5 | 4.9 | 0.2 | 296 | 31 | 33 | 7.3 | 4.5 | 9.8 | 394 | 147 | 2.8 | 1.6 | 42 | |
No adverse clinical changes were noted between the pre and post dosing periods.
AAV1-CB-FL, AAV1- firefly luciferase; AAV5-RL, AAV5- renilla luciferase; AB, Albumin/Globulin; ALB, Albumin; ALP, serum alkaline phosphatase; ALT, serum alanine transaminase (aminotransferase); AST, serum aspartate transaminase (aminotransferase); BILIT, bilirubin (total); BUN/CRE, blood urea nitrogen/creatinine; BUN, blood urea nitrogen; CA, serum calcium; CBC, complete blood count; cDNA, copy deoxyribonucleic acid; CHOL, serum cholesterol (total); CK, serum creatine kinase; CL-S, serum chloride (serum); CRE-S, serum creatinine (serum); DPD, days post-dosing; EDTA, ethylene diamine tetra acetate; F, female; gc, genome copies; GLOBN, serum globulin; GLP, good laboratory practices; GLU, serum glucose; ID (animal), (animal) identification number; K-S, serum potassium; M, male; NA-S, serum sodium; O&P, fecal ova and parasite; PBS, phosphate buffered Saline; PHOS, serum phosphorous; PT, prothrombin time; PTT, partial thromboplastin time; SD, standard deviation; TP, serum protein (total).