Table 7.
Diagnostic performance of Pap test (missing/not done: n = 22), HPV and GynTect as single tests and triage by HPV and GynTect for the detection of CIN3 or cervical cancer (CIN3+)
| Age < 30 | Age ≥ 30 | Total | |||||
|---|---|---|---|---|---|---|---|
| Sensitivity CIN3+ | Specificity CIN3+ | Sensitivity CIN3+ | Specificity CIN3+ | Sensitivity CIN3+ | Specificity CIN3+ | ||
| Pap III+ | Estimate [%] | 74.2 | 62.3 | 86.8 | 72.5 | 82.1 | 69.0 |
| 95% CI [%] | 55.4–88.1 | 49.8–73.7 | 74.7–94.5 | 64.0–80.0 | 72.3–89.6 | 62.1–75.3 | |
| Count | (23/31) | (43/69) | (46/53) | (95/131) | (69/84) | (138/200) | |
| HPV | Estimate [%] | 97.0 | 39.2 | 95.0 | 60.4 | 95.7 | 53.1 |
| 95% CI [%] | 84.2–99.9 | 28.0–51.2 | 86.1–99.0 | 51.8–68.6 | 89.4–98.8 | 46.1–59.9 | |
| Count | (32/33) | (29/74) | (57/60) | (84/139) | (89/93) | (113/213) | |
| GynTect | Estimate [%] | 54.5 | 89.2 | 75.0 | 79.1 | 67.7 | 82.6 |
| 95% CI [%] | 36.4–71.9 | 79.8–95.2 | 62.1–85.3 | 71.4–85.6 | 57.3–77.1 | 76.9–87.5 | |
| Count | (18/33) | (66/74) | (45/60) | (110/139) | (63/93) | (176/213) | |
| GynTect in HPV positives | Estimate [%] | 56.3 | 84.4 | 73.7 | 69.1 | 67.4 | 76.0 |
| 95% CI [%] | 37.7–73.6 | 70.5–93.5 | 60.3–84.5 | 55.2–80.9 | 56.7–77.0 | 66.4–84.0 | |
| Count | (18/32) | (38/45) | (42/57) | (38/55) | (60/89) | (76/100) | |
| HPV and GynTect (Triage) | Estimate [%] | 54.5 | 90.5 | 70.0 | 87.8 | 64.5 | 88.7 |
| 95% CI [%] | 36.4–71.9 | 81.5–96.1 | 56.8–81.2 | 81.1–92.7 | 53.9–74.2 | 83.7–92.6 | |
| Count | (18/33) | (67/74) | (42/60) | (122/139) | (60/93) | (189/213) | |
Triage results are defined as negative if HPV negative or HPV positive but GynTect negative and defined as positive in case of HPV positive and GynTect positive