Table 4.

Putative driver gene sets discovered by QuaDMutEx

Putative driver genes	Estimated
discovered by QuaDMutEx	p-value
GBM: Glioblastoma multiforme
CDKN2B (43) TSFM (16) RB1 (10) ERBB2 (7) ITGB3 TRIM2 WEE1 CHD5 MARK4 CES3 SHH IQGAP1 (1)	0.023
OV: Ovarian cancer
TP53 (299) KRAS (2) RNASE3 (1)	0.010
LUNG: Lung Adenocarcinoma
KRAS (60) STK11 (34) EGFR (30) EPHB1 (4) MAP3K3 (3) ABL1 PAK6 MAST1 CYSLTR2 RPS6KA6 FES (2) BAX PIK3C2B RANBP9 RPSA (1)	0.036
BRCA: Breast Invasive Carcinoma
TP53 (194) PIK3CA (138) GATA3 (80) NBPF1 (27) CTCF (18) ATM (16) FOXA1 (15) TMEM132C (6) CABIN1 SRGAP2 KIAA1310 (5) CASP8AP2 TSNARE1 (4) ADCY1 PITX2 PSG11 (3) ANKRD34B KRT14 MSI1 TWISTNB (2)	0.002

For each gene, in parentheses, we provide the number of patients in the dataset that harbored a mutation in that gene. Genes in bold are present int the DriverDBv2 [7] database of previously discovered cancer drivers