Table 7.

Putative driver gene sets discovered by QuaDMutEx

Putative driver genes	Estimated
discovered by QuaDMutEx	p-value
eTNB: Triple negative breast cancer
TP53 (35) PARK2 (6) ROBO2 DUSP22 (4) SAGE1 ANKRD11 NR3C1 (3) BAP1 BRAF ATG7 (2) ZNF257 IDH3B ZNF826 RP11-119B16.1 PSG5 MSR1 (2)	0.001
eGBM: Glioblastoma multiforme
CDKN2B (52) TP53 (38) NUP107 (9) HLA-E SAC SPRED3	0.001
eHGS: high-grade serous ovarian cancer
TP53 (249) GLI1 (3) ABHD6 CHMP4A EP400 EPS8L3 FRMD1 (2) GPATCH8 MCM4 GFRA1 LPPR4 PTK2 WRN ANKRD36B (2)	0.001
eMTB: METABRIC breast cancer
C17orf37(MIEN1) (82) BAG4 (52) CLNS1A (37) PSG1 (24) C20orf133(MACROD2) (19) BCAS1 (17) PTEN(16) RTF1 ALOXE3 (7) TRA@ AC116165.7-3 (6) TBC1D3P2 (5) CTSK AC116655.7-12 LANCL2 (4) ITSN2 (3) DEFB126 (3) SLC35F3 (2)	0.001

For each gene, in parentheses, we provide the number of patients in the dataset that harbored a mutation in that gene. Genes in bold are present in the DriverDBv2 [7] database of previously discovered cancer drivers