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. 2017 Oct 24;10:168. doi: 10.1186/s13045-017-0526-8

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — NLRs/inflammasome sensors may be either upstream regulators or downstream targets of nuclear receptors in human tissues (tissues: adipose, brain, eye, heart, kidney, liver, lymph node, muscle, pancreas, skin, spleen). a Correlation between inflammasome genes and highly expressed nuclear receptors. b Different correlation tiers show the level of statistically significant correlation between inflammasome genes and highly expressed nuclear receptors. Abbreviations: NOD1/2/3/4: nucleotide-binding oligomerization domain-like receptors 1/2/3/4; NALP2/3/6/9/14: NLR family pyrin domain containing 2/3/6/9/14; NAIP: NLR family apoptosis inhibitory protein; NLRC4: NLR family CARD domain containing 4; ASC: PYD and CARD domain containing; IFI16: interferon gamma-inducible protein 16; CARD8: caspase recruitment domain family member 8