Table 11.
Hormone ligand level changes are associated with inflammatory diseases
| NRNC symbol | Ligand(s) | Inflammatory disease | Ligand level change | PMID |
|---|---|---|---|---|
| Class I—thyroid hormone receptor-like | ||||
| NR1A1 | Thyroid hormone | Inflammatory bowel diseases | ↑ | 8562993 |
| NR1A2 | ||||
| NR1B1 | Vitamin A | Chronic obstructive pulmonary disease | ↓ | 26339144 |
| NR1B2 | ||||
| NR1B3 | ||||
| NR1C1 | Fatty acids, prostaglandins | Inflammatory bowel disease | ↓ | 27631140 |
| NR1C2 | ||||
| NR1C3 | ||||
| NR1F1 | Cholesterol | Atherosclerotic cardiovascular disease | ↑ | 21686232 |
| NR1F2 | ||||
| NR1F3 | ||||
| NR1H3 | Oxysterols | Inflammatory bowel diseases | ↑ | 24024145 |
| NR1H2 | ||||
| NR1H4 | ||||
| Class II—retinoid X receptor-like | ||||
| NR2B1 | Retinoids | Inflammatory intestinal disease | ↓ | 23690441 |
| NR2B2 | ||||
| NR2B3 | ||||
| Class III—estrogen receptor-like | ||||
| NR3A1 | Estrogens | Atherosclerosis | ↓ | 12816884 |
| NR3C1 | Cortisol | Obesity | ↑ | 12466357 |
| NR3C2 | Aldosterone | Renal fibrosis | ↑ | 26730742 |
| NR3C4 | Testosterone | Crohn’s disease | ↓ | 26020563 |