Table 16.
Pro-inflammatory cytokine signaling negatively regulates the expression of nuclear receptors
| Disease | Tissue/cell type | Number | Upregulated gene | Fold* | Downregulated gene | Fold* | PMID/GEO ID | ||
|---|---|---|---|---|---|---|---|---|---|
| Up | Down | ∆ | ∆ | ||||||
| IFN-γ stimulation | EC | 2 | 2 | NR2F1 | 1.39 | NR2B1 | −1.26 | 19553003/GSE3920 | |
| NR3C1 | 1.53 | NR2F6 | −1.36 | ||||||
| IL-1β stimulation | EC | 3 | 7 | NR1H4 | 5.32 | NR1B2 | −3.84 | 21469100/GSE19240 | |
| NR3A1 | 2.21 | NR1B3 | −4.93 | ||||||
| NR5A2 | 6.57 | NR1F1 | −4.72 | ||||||
| NR1F2 | −2.58 | ||||||||
| NR3A2 | −4.94 | ||||||||
| NR3B3 | −11.03 | ||||||||
| NR4A1 | −3.43 | ||||||||
| Human PBMCs-IL-1β and TNF-α stimulations | IL-1β 2 h | PBMC | 0 | 3 | NR1A1 | −14.93 | 23104095/GSE40838 | ||
| NR1I1 | −5.1 | ||||||||
| NR3A2 | −6.54 | ||||||||
| IL-1β 6 h | 0 | 1 | NR5A2 | −23.26 | |||||
| TNF-α 2 h | 1 | 1 | NR1B2 | 38.32 | NR2A1 | −21.11 | |||
| TNF-α 6 h | 2 | 3 | NR1B2 | 27.28 | NR1A2 | −23.92 | |||
| NR3B3 | 4.92 | NR1B3 | −16.22 | ||||||
| NR4A1 | −3.86 | ||||||||
Abbreviations: IFN-γ interferon gamma, IL-1β interleukin-1β, TNF-α tumor necrosis factor-α-like, PBMCs peripheral blood mononuclear cells