Table 20.
Nuclear receptors are significantly changed in caspase-1 and Sirt1 knockout mice, indicating that caspase-1-Sirt1 pathway negatively regulates nuclear receptor expression
| Disease | Tissue/cell type | Number | Upregulated gene | Fold* | Downregulated gene | Fold* | PMID/GEO ID | ||
|---|---|---|---|---|---|---|---|---|---|
| Up | Down | ∆ | ∆ | ||||||
| AopE−/−/Casp1−/− vs. ApoE−/− | Aorta | 3 | 0 | NR1A2 | 1.22 | GSE72448 | |||
| NR1D2 | 1.17 | ||||||||
| NR2C2 | 1.19 | ||||||||
| Adipose | 10 | 1 | NR1A1 | 1.35 | NR6A1 | −1.32 | |||
| NR1C3 | 1.84 | ||||||||
| NR1F1 | 1.78 | ||||||||
| NR1I3 | 1.22 | ||||||||
| NR2A1 | 2.24 | ||||||||
| NR2B1 | 1.52 | ||||||||
| NR3A1 | 1.39 | ||||||||
| NR3C1 | 1.41 | ||||||||
| NR3C4 | 1.66 | ||||||||
| NR4A2 | 1.16 | ||||||||
| Casp1−/−/ASC−/− vs. ASC−/− | White adipose tissue | 7 | 0 | NR1A1 | 1.35 | 21876127/GSE25205 | |||
| NR1C3 | 1.84 | ||||||||
| NR1I3 | 1.22 | ||||||||
| NR2A1 | 1.17 | ||||||||
| NR2B1 | 1.52 | ||||||||
| NR3C4 | 1.65 | ||||||||
| NR4A2 | 1.16 | ||||||||
| Sirt1−/− vs. WT | Treg | 4 | 0 | NR1B1 | 1.2 | 21199917/GSE26425 | |||
| NR1F1 | 1.29 | ||||||||
| NR2F6 | 1.22 | ||||||||
| NR4A3 | 1.29 | ||||||||
| Cardiac-specific transgenic (Tg-Sirt1) mice | Heart | 2 | 6 | NR3C4 | 1.52 | NR1B1 | −3.57 | 22055503/GSE33101 | |
| NR0B2 | 1.35 | NR1B3 | −1.25 | ||||||
| NR1F3 | −2 | ||||||||
| NR1I1 | −1.27 | ||||||||
| NR2B3 | −1.22 | ||||||||
| NR2C1 | −1.22 | ||||||||
| NLRP3 mutation | Adult control | PBMC | 26 | 9 | NR1B1 | 1.22 | NR1F1 | −2.93 | –/GSE43553 |
| NR1B2 | 1.47 | NR1F2 | −1.4 | ||||||
| NR1B3 | 1.43 | NR2C1 | −1.93 | ||||||
| NR1C2 | 1.18 | NR3C1 | −1.38 | ||||||
| NR1C3 | 1.2 | NR3C2 | −1.68 | ||||||
| NR1I1 | 1.73 | NR4A1 | −1.32 | ||||||
| NR1I2 | 1.2 | ||||||||
| NR2A1 | 1.53 | ||||||||
| NR2B3 | 1.25 | ||||||||
| NR2E1 | 1.31 | ||||||||
| NR2E3 | 1.57 | ||||||||
| NR2F1 | 1.2 | ||||||||
| NR3A1 | 1.61 | ||||||||
| NR3A2 | 1.28 | ||||||||
| NR3B1 | 1.34 | ||||||||
| NR4A3 | 1.27 | ||||||||
| NR5A1 | 1.42 | ||||||||
| NR6A1 | 1.3 | ||||||||
| NR0B2 | 1.34 | ||||||||
| Children control | 26 | 11 | NR1A1 | 1.4 | NR1D1 | −1.82 | |||
| NR1A2 | 1.24 | NR1D2 | −1.56 | ||||||
| NR1B1 | 1.31 | NR1F1 | −2.53 | ||||||
| NR1B2 | 1.51 | NR2B2 | −1.44 | ||||||
| NR1B3 | 1.49 | NR2C1 | −2.25 | ||||||
| NR1C3 | 1.32 | NR2C2 | −1.29 | ||||||
| NR1I1 | 1.69 | NR3C1 | −1.3 | ||||||
| NR1I2 | 1.27 | NR3C2 | −1.53 | ||||||
| NR2A1 | 1.66 | NR4A1 | −1.37 | ||||||
| NR2A2 | 1.22 | NR4A2 | −4.23 | ||||||
| NR2E1 | 1.21 | ||||||||
| NR2E3 | 1.55 | ||||||||
| NR2F1 | 1.24 | ||||||||
| NR2F6 | 1.26 | ||||||||
| NR3A1 | 1.23 | ||||||||
| NR3A2 | 1.41 | ||||||||
| NR3B1 | 1.65 | ||||||||
| NR3C3 | 1.21 | ||||||||
| NR4A3 | 1.23 | ||||||||
| NR5A1 | 1.41 | ||||||||
| NR6A1 | 1.29 | ||||||||
| NR0B2 | 1.34 | ||||||||
Abbreviations: ApoE−/− apolipoprotein E-deficient mice, Casp1−/− caspase-1-deficient mice, HFD high fat diet, ASC−/− PYD and CARD domain-containing deficient mice, Sirt 1−/− sirtuin 1-deficient mice; WT wild-type mice, NLRP3 NLR family pyrin domain containing 3 deficient mice; vs. versus