Table 7.
Several findings in this study are significantly novel in comparing to what is published
| Items | Expression profile of Nuclear receptors | |
|---|---|---|
| Our findings | Cell paper (PMID: 16923397) | |
| The number of nuclear receptors | 48 known human NR | 49 known mouse NR |
| Species | Human and mouse | Mouse |
| The number of tissues | 21 human tissues and 17 mouse tissues | Only 39 mouse tissues |
| Analysis method | cDNA cloning and DNA sequencing experiments (EST database) | RT-PCR (high-throughput capacity) |
| Advantage of the method | More precise | – |
| NR groups based on their tissue distribution | – | Restricted (11), widespread (17), all tissues (21) |
| NR groups based on the expression level of nuclear receptors | Super high (12), high (5), low (3), super low activation (28) | – |
| Tissue groups based on number of highly expressed nuclear receptors | Super high (3/2 in human/mouse), high (4/5 in human/mouse), low (3/5 in human/mouse), supper low varieties (6/2 in human/mouse) | – |
| CNS (# human/mouse) | Brain, eye, nerve (19/1) | Eye, brainstem, cerebellum, cerebrum, corpus striatum, olfactory bulb, spinal cord, hypothalamus, and pituitary (11) |
| Gastroenteric system (# human/mouse) | Stomach, pancreas (5/5) | Tongue, stomach, duodenum, jejunum, ileum, colon, and gall bladder (13) |
| Metabolic system (# human/mouse) | Liver, kidney, adrenal gland, adipose, intestine, and muscle (40/14) | Liver, kidney, brown and white adipose, and muscle (13) |
| Immune system (# human/mouse) | Spleen and lymph node (4/6) | Spleen and thymus (2) |
| Cardiovascular system (# human/mouse) | Heart, lung, blood and trachea (19/6) | Aorta, heart, and lung (8) |
| Structural system (# human/mouse) | Skin (1/7) | Bone and skin (5) |