Table 4.
Predictive Factors for Local Failure in Univariate Analyses
| Factor | HR | 95% CI | P | |
|---|---|---|---|---|
| Age | <68 y | Reference | ||
| ≥68 y | 0.589 | 0.188‐1.841 | .360 | |
| Sex | Male | Reference | ||
| Female | 2.881 | 0.931‐8.910 | .066 | |
| ECOG performance status | 0/1 | Reference | ||
| 2 | 0.601 | 0.078‐4.629 | .630 | |
| Type of chronic hepatitis | HCV | Reference | ||
| HBV or other | 1.471 | 0.448‐4.834 | .520 | |
| Prior treatment | None | Reference | ||
| Recurrence after treatment | 0.495 | 0.152‐1.618 | .240 | |
| Child‐Pugh class | A | Reference | ||
| B | 1.073 | 0.294‐3.917 | .920 | |
| ICG R15 | ≤20% | Reference | ||
| >20% | 1.376 | 0.411‐4.611 | .610 | |
| Clinical stage | I/II | Reference | ||
| IIIA/IVA | 1.376 | 0.446‐4.245 | .580 | |
| Maximum tumor size | ≤30 mm | Reference | ||
| >30 mm, ≤50 mm | 4.850 | 0.622‐37.800 | .130 | |
| >50 mm | 4.329 | 0.495‐37.890 | .190 | |
| Tumors in target volume | Single | Reference | ||
| Multiple | 0.665 | 0.150‐2.937 | .590 | |
| Tumor thrombus | Absent | Reference | ||
| Present | 1.920 | 0.527‐7.002 | .320 | |
| Target volume | <158 mL | Reference | ||
| ≥158 mL | 1.431 | 0.460‐4.448 | .540 | |
| Fractions, No. | 4 | Reference | ||
| 8 | 0.741 | 0.135‐4.077 | .730 | |
| 12 | 0.670 | 0.192‐2.339 | .530 | |
| Fields, No. | 2 | Reference | ||
| 3/4 | 2.400 | 0.732‐7.871 | .150 | |
| Protocol | 9603 | Reference | ||
| 0004 | 0.569 | 0.159‐2.013 | .380 | |
Abbreviations: CI, confidence interval; ECOG, Eastern Cooperative Oncology Group; HBV, hepatitis B virus; HCV, hepatitis C virus; HR, hazard ratio; ICG R15, indocyanine green retention rate at 15 minutes.