Table 4.
Published Studies of Capecitabine, Vinorelbine, and Trastuzumab Combinations
| Chemotherapy Regimen |
Source | No. of Patients |
TTP, mo | OS, mo | RR, % | CR/PR, % |
|---|---|---|---|---|---|---|
| Cap and T (2nd line and beyond) | Bartsch et al (20) | 40 | 8 | 24 | 20 | 2.5/17.5 |
| Cap (1st and 2nd line) | von Minckwitz et al (21) | 78 | 5.6 | 20.4 | 27 | NR |
| Cap and T (1st and 2nd line) | von Minckwitz et al (21) | 78 | 8.2 | 25.5 | 48 | NR |
| Cap and T (2nd or 3rd line) | Schaller et al (22) | 27 | 6.7 | 28 | 45 | 15/30 |
| V and T (1st and 2nd line) | Burstein et al (5) | 40 | 8.2 | 17 2nd line | 75 | 8/68 |
Abbreviations: Cap, capecitabine; CR, complete response; NR, not reported; OS, overall survival; PR, partial response; RR, response rate; T, trastuzumab; TTP, time to progression; V, vinorelbine.