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Inhibition constants of wild-type and BLIP K74T:W112D for various β-lactamases.
| β-lactamase | Wt BLIP Ki (nM) |
K74T:W112D BLIP Ki (nM) |
Fold Increase in Ki (K74T:W112D/wt BLIP) |
|---|---|---|---|
| KPC-2 | 1.2 | 0.4 | 0.3 |
| TEM-1 | 0.5 | >10000 | >20000 |
| SHV-1 | 1100 | >10000 | >9 |
| CTX-M-14 | 810 | >10000 | >12 |
| SME-1 | 2.4 | 450 | 188 |
